100525 + Interview Questions in GENERAL QA IN GENERAL AWARENESS

1.	The major catabolic product of pyrimidines in human is (A) β-Alanine (B) Urea (C) Uric acid (D) Guanine
Answer» (A) β-Alanine

Discussion

2.	Hormone receptors that stimulate cAMP production (A) are part of a complex of two proteins that transform the external signal into internal cAMP production (B) are proteins distinct and separate from those that catalyze the production of cAMP (C) cause release of the catalytic subunit upon binding of the hormone (D) are not very specific and bind a number of different hormones
Answer» (B) are proteins distinct and separate from those that catalyze the production of cAMP

Discussion

3.	Reducing equivalents from pyruvate enter the mitochondrial respiratory chain at (A) FMN (B) NAD (C) Coenzyme Q (D) Cyt b
Answer» Correct option (B) NAD

Discussion

4.	One of the site of phsosphorylation in mitochondrial respiratory chain is (A) Between FMN and coenzyme Q (B) Between coenzyme Q and cyt b (C) Between cytochrome b and cytochrome c1 (D) Between cytochrome c1 and cytochrome c
Answer» (C) Between cytochrome b and cytochrome c₁

Discussion

5.	Reducing equivalents from succinate enter the mitochondrial respiratory chain at (A) NAD (B) Coenzyme Q (C) FAD (D) Cyt c
Answer» Correct option (C) FAD

Discussion

6.	Which of the following component of respiratory chain is not attached to the inner mitochondrial membrane? (A) Coenzyme Q (B) Cytochrome c (C) Both (A) and (B) (D) None of these
Answer» (C) Both (A) and (B)

Discussion

7.	The sequence of the redox carrier in respiratory chain is (A) NAD—FMN—Q—cyt b—cyt c1—cyt c—cyt aa3 → O2 (B) FMN—Q—NAD—cyt b—cyt aa3—cyt c1— cyt c → O2 (C) NAD—FMN—Q—cyt c1—cyt c—cyt b—cyt aa3 → O2 (D) NAD—FMN—Q—cyt b—cyt aa3—cyt c—cyt c1 → O2
Answer» (A) NAD—FMN—Q—cyt b—cyt c₁—cyt c—cyt aa₃ → O₂

Discussion

8.	Thyrotropin releasing hormone is a (A) Dipeptide (B) Tripeptide (C) Octapeptide (D) Decapeptide
Answer» (B) Tripeptide

Discussion

9.	Catabolism of thymidylate gives (A) α-alanine (B) β-alanine (C) α-aminoisobutyrate (D) β-aminoisobutyrate
Answer» (D) β-aminoisobutyrate

Discussion

10.	The redox carriers are grouped into respiratory chain complex (A) In the inner mitochondrial membrane (B) In mitochondiral matrix (C) On the outer mitochondrial membrane (D) On the inner surface of outer mitochondrial membrane
Answer» (A) In the inner mitochondrial membrane

Discussion

11.	Hypthalamo _________ gonadal oxis, fill up the blank with the suitable word. (A) Adrenal (B) Thyroid (C) Hypophyseal (D) Pancreatic
Answer» (C) Hypophyseal

Discussion

12.	Which one of the following causes frame shift mutation?(A) Transition (B) Transversion (C) Deletion (D) Substitution of purine to pyrimidine
Answer» (C) Deletion

Discussion

13.	Insulin like growth hormones are produced by (A) Hypophysis (B) Liver (C) Pancreas (D) Thyroid
Answer» Correct option (B) Liver

Discussion

14.	Lack of Glucocorticoids and mineral corticoids might be consequence of which of the following defects in the adrenal cortex? (A) Androstenadione deficiency (B) Estrone deficiency (C) 17 α-OH progesterone deficiency (D) C- α-Hydroxylase deficiency
Answer» (D) C- α-Hydroxylase deficiency

Discussion

15.	In pheochromocytoma, urine will have (A) FILGU (B) VMA (C) 5 HIAA (D) Lysine and Arginine
Answer» Correct option (B) VMA

Discussion

16.	The serum estradiol level in men is (A) 0–5 pg/ml (B) 5–10 pg/ml (C) 24–68 pg/ml (D) 40–60 pg/ml
Answer» (A) 0–5 pg/ml

Discussion

17.	Cancer cells may become resistant to amethopterin by(A) Developing mechanisms to destroy amethopterin(B) Amplification of dihydrofolate reducatse gene(C) Mutation in the dihydrofolate reductase gene so that the enzyme is no longer inhibited by amethopterin(D) Developing alternate pathway of thymidylate synthesis
Answer» (B) Amplification of dihydrofolate reducatse gene

Discussion

18.	CTP synthetase forms CTP from (A) CDP and inorganic phosphate (B) CDP and ATP (C) UTP and glutamine (D) UTP and glutamate
Answer» (C) UTP and glutamine

Discussion

19.	Amethopterin and aminopterin decrease the synthesis of (A) TMP (B) UMP (C) CMP (D) All of these
Answer» Correct option (A) TMP

Discussion

20.	Myeloma cells are lacking in(A) TMP synthetase(B) Formyl transferase(C) HGPRT(D) All of these
Answer» Correct option (C) HGPRT

Discussion

21.	d-UMP is converted to TMP by (A) Methylation (B) Decarboxylation (C) Reduction (D) Deamination
Answer» (A) Methylation

Discussion

22.	What is the numeric relation between pyrimidine and purine bases in the DNA molecule? Is that relation valid in RNA molecules?
Answer» The DNA molecule is made of two bound polynucleotide chains that form a helical structure (the double helix). The binding of the two chains is between their nitrogen-containing bases and it always obeys the following rules: adenine (A), a purine base binds with thymine (T), a pyrimidine base, and guanine (G), a purine base binds to cytosine (C), a pyrimidine base. Therefore in one molecule of DNA there will be the same number of adenine (A) and thymine (T) and same number of cytosine (C) and guanine (G). The quantities of purine and of pyrimidine bases then will also be the same in a 50% proportion for each type. Relation A = T and C = G, or A/T = C/G = 1, is called Chargaff’s relation and the pairing rules described above are known as Chargaff’s rules. In RNA there are not two nucleotide chains. RNA is a simple chain molecule and there is no necessary proportionality of nitrogen-containing bases to form it.

22.

What is the numeric relation between pyrimidine and purine bases in the DNA molecule? Is that relation valid in RNA molecules?

Answer»

The DNA molecule is made of two bound polynucleotide chains that form a helical structure (the double helix). The binding of the two chains is between their nitrogen-containing bases and it always obeys the following rules: adenine (A), a purine base binds with thymine (T), a pyrimidine base, and guanine (G), a purine base binds to cytosine (C), a pyrimidine base. Therefore in one molecule of DNA there will be the same number of adenine (A) and thymine (T) and same number of cytosine (C) and guanine (G). The quantities of purine and of pyrimidine bases then will also be the same in a 50% proportion for each type. Relation A = T and C = G, or A/T = C/G = 1, is called Chargaff’s relation and the pairing rules described above are known as Chargaff’s rules.

In RNA there are not two nucleotide chains. RNA is a simple chain molecule and there is no necessary proportionality of nitrogen-containing bases to form it.

Discussion

23.	For the synthesis of TMP from dump, a coenzyme is required which is (A) N10- Formyl tetrahydrofolate (B) N5- Methyl tetrahydrofolate (C) N5, N10- Methylene tetrahydrofolate (D) N5- Formimino tetrahydrofolate
Answer» (C) N⁵, N¹⁰- Methylene tetrahydrofolate

Discussion

24.	In purine biosynthesis ring closure in the molecule formyl glycinamide ribosyl-5- phosphate requires the cofactors: (A) ADP (B) NAD (C) FAD (D) ATP and Mg++
Answer» (D) ATP and Mg⁺⁺

Discussion

25.	Tetrahydrofolate is required as a coenzyme for the synthesis of (A) UMP (B) CMP (C) TMP (D) All of these
Answer» Correct option (C) TMP

Discussion

26.	A nucleoside consists of (A) Nitrogenous base (B) Purine or pyrimidine base + sugar (C) Purine or pyrimidine base + phosphorous (D) Purine + pyrimidine base + sugar + phosphorous
Answer» (B) Purine or pyrimidine base + sugar

Discussion

27.	In DNA, genetic information is located in (A) Purine bases (B) Pyrimidine bases (C) Purine and pyrimidine bases (D) sugar
Answer» (C) Purine and pyrimidine bases

Discussion

28.	N10-formyl and N5N10-methenyl tetrahydrofolate contributes purine carbon atoms at position (A) 4 and 6 (B) 4 and 5 (C) 5 and 6 (D) 2 and 8
Answer» Correct option (D) 2 and 8

Discussion

29.	Pyrimidine and purine nucleoside biosynthesis share a common precursor: (A) PRPP (B) Glycine (C) Fumarate (D) Alanine
Answer» Correct option (A) PRPP

Discussion

30.	In the purine nucleus, carbon 6 is contributed by (A) Glycine (B) CO2 (C) Aspartate (D) Glutamine
Answer» Correct option (B) CO₂

Discussion

31.	The four nitrogen atoms of purines are derived from (A) Urea and NH3 (B) NH3, Glycine and Glutamate (C) NH3, Asparate and Glutamate (D) Aspartate, Glutamine and Glycine
Answer» (D) Aspartate, Glutamine and Glycine

Discussion

32.	In humans, the principal break down product of purines is (A) NH3 (B) Allantin (C) Alanine (D) Uric acid
Answer» (D) Uric acid

Discussion

33.	In purine nucleus nitrogen atom at 1 position is derived from (A) Aspartate (B) Glutamate (C) Glycine (D) Alanine
Answer» (A) Aspartate

Discussion

34.	Which one of the following contributes nitrogen atoms to both purine and pyrimidine rings? (A) Aspartate (B) Carbanoyl phosphate (C) Carbondioxide (D) Tetrahydrofolate
Answer» (A) Aspartate

Discussion

35.	Aspartate contributes the following carbon atoms of the pyrimidine nucelus: (A) C2 and C4 (B) C5 and C6 (C) C2, C4 and C6 (D) C4, C5 and C6
Answer» (D) C₄, C₅ and C₆

Discussion

36.	The two nitrogen of the pyrimidine ring are contributed by (A) Ammonia and glycine (B) Asparate and carbamoyl phosphate (C) Glutamine and ammonia (D) Aspartate and ammonia
Answer» (B) Asparate and carbamoyl phosphate

Discussion

37.	Dietary purines are catabolised in (A) Liver (B) Kidneys (C) Intesitnal mucosa (D) All of these
Answer» (C) Intesitnal mucosa

Discussion

38.	The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP
Answer» Correct option (A) UMP

38.

The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP

Answer»

Correct option (A) UMP

Discussion

39.	The nitrogen atoms of pyrimidine nucleus are provided by (A) Glutamate(B) Glutamate and aspartate (C) Glutamine (D) Glutamine and aspartate
Answer» (D) Glutamine and aspartate

Discussion

40.	The carbon atom at position 2 of pyrimidine nucleus is contributed by (A) CO2 (B) Glycine (C) Aspartate (D) Glutamine
Answer» Correct option ( A) CO₂

40.

The carbon atom at position 2 of pyrimidine nucleus is contributed by (A) CO2 (B) Glycine (C) Aspartate (D) Glutamine

Answer»

Correct option ( A) CO₂

Discussion

41.	De novo synthesis of pyrimidine nucleotides occurs in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Ribosomes
Answer» Correct option (B) Cytosol

Discussion

42.	Nitrogen at position 3 of pyrimidine nucleus comes from (A) Glutamine (B) Glutamate (C) Glycine (D) Aspartate
Answer» (A) Glutamine

Discussion

43.	Nitrogen at position 1 of pyrimidine nucleus comes from (A) Glutamine (B) Glutamate (C) Glycine (D) Aspartate
Answer» (D) Aspartate

Discussion

44.	PRPP synthetase is allosterically inhibited by (A) AMP (B) ADP (C) GMP (D) All of these
Answer» (D) All of these

44.

PRPP synthetase is allosterically inhibited by (A) AMP (B) ADP (C) GMP (D) All of these

Answer»

(D) All of these

Discussion

45.	A common substrate of HGPRTase, APRTase and PRPP glutamyl amidotransferase is(A) Ribose 5 phosphate (B) Phosphoribosyl pyrophosphate (C) Hypoxanthine (D) Adenosine
Answer» (B) Phosphoribosyl pyrophosphate

Discussion

46.	De novo synthesis of pyrimidine nucleotides is regulated by (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Both (A) and (B) (D) None of these
Answer» (C) Both (A) and (B)

Discussion

47.	Two nitrogen of the pyrimidines ring are obtained from(A) Glutamine and Carbamoyl-p (B) Asparate and Carbamoyl-p (C) Glutamate and NH3 (D) Glutamine and NH3
Answer» (B) Asparate and Carbamoyl-p

Discussion

48.	The following abnormality in PRPP synthetase can cause primary gout:(A) High Vmax (B) Low Km (C) Resistance to allosteric inihbition. (D) All of these
Answer» (D) All of these

Discussion

49.	Cytosolic carbamoyl phosphate synthetase is activated by (A) Glutamine (B) PRPP (C) ATP (D) Aspartate
Answer» Correct option (B) PRPP

49.

Cytosolic carbamoyl phosphate synthetase is activated by (A) Glutamine (B) PRPP (C) ATP (D) Aspartate

Answer»

Correct option (B) PRPP

Discussion

50.	Proton motive force is the net sum of how many gradient components?(a) 1(b) 2(c) 3(d) 4
Answer» Right option is (b) 2 Easiest explanation: Proton motive force is a measure of electrochemical gradient. Because the translocation of protons across the membrane lead to a difference of hydrogen ion concentration and a difference of charge, the energy present in both components of the proton electrochemical gradient are combined and expressed as proton motive force.

Discussion

Explore topic-wise InterviewSolutions in Current Affairs.

The major catabolic product of pyrimidines in human is (A) β-Alanine (B) Urea (C) Uric acid (D) Guanine

Reducing equivalents from pyruvate enter the mitochondrial respiratory chain at (A) FMN (B) NAD (C) Coenzyme Q (D) Cyt b

One of the site of phsosphorylation in mitochondrial respiratory chain is (A) Between FMN and coenzyme Q (B) Between coenzyme Q and cyt b (C) Between cytochrome b and cytochrome c1 (D) Between cytochrome c1 and cytochrome c

Reducing equivalents from succinate enter the mitochondrial respiratory chain at (A) NAD (B) Coenzyme Q (C) FAD (D) Cyt c

Which of the following component of respiratory chain is not attached to the inner mitochondrial membrane? (A) Coenzyme Q (B) Cytochrome c (C) Both (A) and (B) (D) None of these

The sequence of the redox carrier in respiratory chain is (A) NAD—FMN—Q—cyt b—cyt c1—cyt c—cyt aa3 → O2 (B) FMN—Q—NAD—cyt b—cyt aa3—cyt c1— cyt c → O2 (C) NAD—FMN—Q—cyt c1—cyt c—cyt b—cyt aa3 → O2 (D) NAD—FMN—Q—cyt b—cyt aa3—cyt c—cyt c1 → O2

Thyrotropin releasing hormone is a (A) Dipeptide (B) Tripeptide (C) Octapeptide (D) Decapeptide

Catabolism of thymidylate gives (A) α-alanine (B) β-alanine (C) α-aminoisobutyrate (D) β-aminoisobutyrate

The redox carriers are grouped into respiratory chain complex (A) In the inner mitochondrial membrane (B) In mitochondiral matrix (C) On the outer mitochondrial membrane (D) On the inner surface of outer mitochondrial membrane

Hypthalamo _________ gonadal oxis, fill up the blank with the suitable word. (A) Adrenal (B) Thyroid (C) Hypophyseal (D) Pancreatic

Which one of the following causes frame shift mutation?(A) Transition (B) Transversion (C) Deletion (D) Substitution of purine to pyrimidine

Insulin like growth hormones are produced by (A) Hypophysis (B) Liver (C) Pancreas (D) Thyroid

Lack of Glucocorticoids and mineral corticoids might be consequence of which of the following defects in the adrenal cortex? (A) Androstenadione deficiency (B) Estrone deficiency (C) 17 α-OH progesterone deficiency (D) C- α-Hydroxylase deficiency

In pheochromocytoma, urine will have (A) FILGU (B) VMA (C) 5 HIAA (D) Lysine and Arginine

The serum estradiol level in men is (A) 0–5 pg/ml (B) 5–10 pg/ml (C) 24–68 pg/ml (D) 40–60 pg/ml

CTP synthetase forms CTP from (A) CDP and inorganic phosphate (B) CDP and ATP (C) UTP and glutamine (D) UTP and glutamate

Amethopterin and aminopterin decrease the synthesis of (A) TMP (B) UMP (C) CMP (D) All of these

Myeloma cells are lacking in(A) TMP synthetase(B) Formyl transferase(C) HGPRT(D) All of these

d-UMP is converted to TMP by (A) Methylation (B) Decarboxylation (C) Reduction (D) Deamination

What is the numeric relation between pyrimidine and purine bases in the DNA molecule? Is that relation valid in RNA molecules?

For the synthesis of TMP from dump, a coenzyme is required which is (A) N10- Formyl tetrahydrofolate (B) N5- Methyl tetrahydrofolate (C) N5, N10- Methylene tetrahydrofolate (D) N5- Formimino tetrahydrofolate

In purine biosynthesis ring closure in the molecule formyl glycinamide ribosyl-5- phosphate requires the cofactors: (A) ADP (B) NAD (C) FAD (D) ATP and Mg++

Tetrahydrofolate is required as a coenzyme for the synthesis of (A) UMP (B) CMP (C) TMP (D) All of these

A nucleoside consists of (A) Nitrogenous base (B) Purine or pyrimidine base + sugar (C) Purine or pyrimidine base + phosphorous (D) Purine + pyrimidine base + sugar + phosphorous

In DNA, genetic information is located in (A) Purine bases (B) Pyrimidine bases (C) Purine and pyrimidine bases (D) sugar

N10-formyl and N5N10-methenyl tetrahydrofolate contributes purine carbon atoms at position (A) 4 and 6 (B) 4 and 5 (C) 5 and 6 (D) 2 and 8

Pyrimidine and purine nucleoside biosynthesis share a common precursor: (A) PRPP (B) Glycine (C) Fumarate (D) Alanine

In the purine nucleus, carbon 6 is contributed by (A) Glycine (B) CO2 (C) Aspartate (D) Glutamine

The four nitrogen atoms of purines are derived from (A) Urea and NH3 (B) NH3, Glycine and Glutamate (C) NH3, Asparate and Glutamate (D) Aspartate, Glutamine and Glycine

In humans, the principal break down product of purines is (A) NH3 (B) Allantin (C) Alanine (D) Uric acid

In purine nucleus nitrogen atom at 1 position is derived from (A) Aspartate (B) Glutamate (C) Glycine (D) Alanine

Which one of the following contributes nitrogen atoms to both purine and pyrimidine rings? (A) Aspartate (B) Carbanoyl phosphate (C) Carbondioxide (D) Tetrahydrofolate

Aspartate contributes the following carbon atoms of the pyrimidine nucelus: (A) C2 and C4 (B) C5 and C6 (C) C2, C4 and C6 (D) C4, C5 and C6

The two nitrogen of the pyrimidine ring are contributed by (A) Ammonia and glycine (B) Asparate and carbamoyl phosphate (C) Glutamine and ammonia (D) Aspartate and ammonia

Dietary purines are catabolised in (A) Liver (B) Kidneys (C) Intesitnal mucosa (D) All of these

The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP

The nitrogen atoms of pyrimidine nucleus are provided by (A) Glutamate(B) Glutamate and aspartate (C) Glutamine (D) Glutamine and aspartate

The carbon atom at position 2 of pyrimidine nucleus is contributed by (A) CO2 (B) Glycine (C) Aspartate (D) Glutamine

De novo synthesis of pyrimidine nucleotides occurs in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Ribosomes

Nitrogen at position 3 of pyrimidine nucleus comes from (A) Glutamine (B) Glutamate (C) Glycine (D) Aspartate

Nitrogen at position 1 of pyrimidine nucleus comes from (A) Glutamine (B) Glutamate (C) Glycine (D) Aspartate

PRPP synthetase is allosterically inhibited by (A) AMP (B) ADP (C) GMP (D) All of these

A common substrate of HGPRTase, APRTase and PRPP glutamyl amidotransferase is(A) Ribose 5 phosphate (B) Phosphoribosyl pyrophosphate (C) Hypoxanthine (D) Adenosine

De novo synthesis of pyrimidine nucleotides is regulated by (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Both (A) and (B) (D) None of these

Two nitrogen of the pyrimidines ring are obtained from(A) Glutamine and Carbamoyl-p (B) Asparate and Carbamoyl-p (C) Glutamate and NH3 (D) Glutamine and NH3

The following abnormality in PRPP synthetase can cause primary gout:(A) High Vmax (B) Low Km (C) Resistance to allosteric inihbition. (D) All of these

Cytosolic carbamoyl phosphate synthetase is activated by (A) Glutamine (B) PRPP (C) ATP (D) Aspartate

Proton motive force is the net sum of how many gradient components?(a) 1(b) 2(c) 3(d) 4