1.

Consider the following alkyl halides ( 1) (CH_3)_3CBr , (2)CH_3Br , (3)C_2H_5Br , (4)CH_3CHBr CH_3 Arrange these alkyl halides in decreasing order of reactivity in Williamson reaction.

Answer»

1 gt 4 gt 3 gt 2
1 gt 2 gt 3 gt 4
4 gt 3 gt 2 gt1
2 gt 3 gt 4 gt 1

Solution :The Williamson REACTION involves NUCLEOPHILIC SUBSTITUTION of ALKOXIDE ion. It is strictly analogous to the preparation of alcohols by treatment of alkyl halide with aqueous NaOH. Alkyl halides undergoes substitution reaction most readily , t-butyl bromide are inert to nucleophilic substitution because they show maximum steric hindrance to the approaching nucleophile. Thus, reactivity of alkyl halides TOWARDS Williamson reaction is , `1^@ RX gt 2^@ RX gt 3^@ RX `


Discussion

No Comment Found

Related InterviewSolutions