Enzyme X catalyzes hydrolysis of GTP into GDP. The GTP-bound form of X transmits a signal that leads to cell proliferation. The GDP-bound form does transmit any such signal. Mutations in X are found in many cancers. Which of the following alterations of X are most likely to contribute to cancer ?A. Mutations that increase the of X for GDPB. Mutations that decrease the affinity of X for GTPC. Mutations that decrease the rate of GTP hydrolysisD. Mutations that prevent expression of enzyme X.

Enzyme X catalyzes hydrolysis of GTP into GDP. The GTP-bound form of X

1.	Enzyme X catalyzes hydrolysis of GTP into GDP. The GTP-bound form of X transmits a signal that leads to cell proliferation. The GDP-bound form does transmit any such signal. Mutations in X are found in many cancers. Which of the following alterations of X are most likely to contribute to cancer ?A. Mutations that increase the of X for GDPB. Mutations that decrease the affinity of X for GTPC. Mutations that decrease the rate of GTP hydrolysisD. Mutations that prevent expression of enzyme X.
Answer» Correct Answer - C `"GTP-X Complex"to"Active cell division"` `"GDP-X Complex"to"No cell division"` `and GTPunderset("X enzyme")overset("Hydrolysis")toGDP` Mutation cause the decrease of rate of hydrolysis of GTP. Thus GTP-X complex remain present for long time cell division become uncontrolled.

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