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Ester given nucleophilic additionreactionfollowed by eliminationreaction withcarbon nucleophile . Whencarbon nucleophileis of anesterthenthe reactionis knowas Claisencondensationreaction. This reactions is alsocarrieout betweenester and aketone. Asuccessful Claisencondensationrequires an ester withtwo alpha- hydrogensand aan equivalentamountof base ratherthan acatayticamount of base . Consider the givereactionCH_(3) - COOC_(2)H_(5) underset(C_(2)H_(5)OH)overset(C_(2)H_(3)ONa) to "enolate ion" underset("Claisen condensation")overset("ester(X)")to ProductFor theabovereactionthe mostreactiveesteris : |
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Answer» `C_(6)H_(5)CO OC_(2)H_(5)` |
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