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Explain the role of allosteric site in enzyme inhibition ? |
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Answer» Solution :Some drugs do not bind to the enzyme.s active site. These bind to a different site of enzyme which is CALLED allosteric site. This binding of INHIBITOR at allosteric site changes the SHAPE of the active site in such a way that substrate cannot recognise it. If the bond formed between an enzyme and an inhibitor is a strong covalent bond and cannot be broken easily, then the enzyme is BLOCKED permanently. The body then degrades the enzyme-inhibitor complex and synthesises the new enzyme. |
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