There are two MAIN models that explain the formation of the enzyme-substrate COMPLEX the lock and key model and the induced fit model.

In the lock and key model, the enzyme has a region with specific spatial conformation for the BINDING of the substrate. In the induced fit model, the binding of the substrate induces a CHANGE in the spatial configuration of the enzyme for the substrate to fit.

Enzyme Activity: lock and key model induced fit model.

There are two main models that explain the formation of the enzyme-substrate complex the lock and key model and the induced fit model.

In the lock and key model, the enzyme has a region with specific spatial conformation for the binding of the substrate. In the induced fit model, the binding of the substrate induces a change in the spatial configuration of the enzyme for the substrate to fit.

Enzyme Activity: lock and key model induced fit model.