Hofmann rearrangement In the Hoffmann rearrangement an unsubstituted amide is treated with sodium hydroxide and bromine to give a primary amine that has one carbon lesser than starting amide. R-oversetoverset(O)(||)C-NH_2+NaOH+Br_2toR-N=underset("isocyanate")(C=O)overset("hydrolysis")toR-NH_2 Mech : If the migrating group is chiral then its configuration is retained . Electron releasing effects in the migrating group increases reactivity of Hofmann rearrangement. Arrange the following amides according to their relative reactivity when react with Br_2 in excess of strong base

Hofmann rearrangement In the Hoffmann rearrangement an unsubstituted

1.	Hofmann rearrangement In the Hoffmann rearrangement an unsubstituted amide is treated with sodium hydroxide and bromine to give a primary amine that has one carbon lesser than starting amide. R-oversetoverset(O)(\|\|)C-NH_2+NaOH+Br_2toR-N=underset("isocyanate")(C=O)overset("hydrolysis")toR-NH_2 Mech : If the migrating group is chiral then its configuration is retained . Electron releasing effects in the migrating group increases reactivity of Hofmann rearrangement. Arrange the following amides according to their relative reactivity when react with Br_2 in excess of strong base
Answer» IVgtIgtIIgtIII IIgtIgtIIIgtIV IIgtIVgtIIIgtI IIgtIgtIVgtIII Solution :Electron donating GROUPS, ACCELERATES the process of REARRANGEMENT & electron with DRAWING groups retard it.