Hofmann rearrangement In the Hoffmann rearrangement an unsubstituted amide is treated with sodium hydroxide and bromine to give a primary amine that has one carbon lesser than starting amide. R-oversetoverset(O)(||)C-NH_2+NaOH+Br_2toR-N=underset("isocyanate")(C=O)overset("hydrolysis")toR-NH_2 Mech : If the migrating group is chiral then its configuration is retained . Electron releasing effects in the migrating group increases reactivity of Hofmann rearrangement. H_3C-H_2C-undersetundersetunderset((R))(CH_3)(|)overset(**)CH-oversetoverset(O)(||)C-NH_2+CH_3-CH_2-undersetundersetunderset((S))(CH_3)(|)oversetoverset(D)(|)C-oversetoverset(O)(||)C-overset(15)(NH_2)overset(Br_2//KOH)toProducts

Hofmann rearrangement In the Hoffmann rearrangement an unsubstituted

1.	Hofmann rearrangement In the Hoffmann rearrangement an unsubstituted amide is treated with sodium hydroxide and bromine to give a primary amine that has one carbon lesser than starting amide. R-oversetoverset(O)(\|\|)C-NH_2+NaOH+Br_2toR-N=underset("isocyanate")(C=O)overset("hydrolysis")toR-NH_2 Mech : If the migrating group is chiral then its configuration is retained . Electron releasing effects in the migrating group increases reactivity of Hofmann rearrangement. H_3C-H_2C-undersetundersetunderset((R))(CH_3)(\|)overset(**)CH-oversetoverset(O)(\|\|)C-NH_2+CH_3-CH_2-undersetundersetunderset((S))(CH_3)(\|)oversetoverset(D)(\|)C-oversetoverset(O)(\|\|)C-overset(15)(NH_2)overset(Br_2//KOH)toProducts
Answer» B & C both are CORRECT Solution :In Hofmann rearrangement CONFIGURATION of central atom REMAIN uncharged as the rearragement is through cross over.