Saved Bookmarks
| 1. |
Illustrate with examples the limitations of Williamson synthesis for the preparation of certain types of ethers. |
|
Answer» Solution :`to` The Williamson synthesis is not a SUITABLE method for the preparation of unsymmetrical ETHERS where compound contains secondary or tertiary ALKYL groups. For example, the reaction between tert-butyl bromide and sodium methoxide yield alkenes. This is because of sodium methoxide is strong base apart from a nucleophile and as a result, the elimination dominates over substitution reaction. `CH_(3)- underset(CH_(3))underset(|)OVERSET(CH_(3))overset(|)C- Br+ overset(+)Nabar(underset(* *)overset(* *)O)-CH_(3) to CH_(3)- underset(CH_(3))underset(|)C= CH_(2)+NaBr+ CH_(3)OH` |
|