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In what respect do prontosil and salvarsan resemble. Is there may resemblance between azo dye and prontosil? Explain. |
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Answer» Solution :Prontosi, also called sulfamido chrysoidine, trade name of the first synthetic drug used in the treatment of general bacterialinfections in humans. Prontosil resulted from research, directed by German chemist and pathologist Gerhard Domagk, on the antibactierial action of azo dyes. A red azo dye of LOW toxicity, prontosil was shown by Domagk to precent mortality in mice infected with Streptococcus bacteria. The dye was also effective in controlling staphloccus infections in rabbits. WITHIN a relativity SHORT period, it was demonstratedthat prontosil was effective not ony in combating experiment infections in animals but also Streptococcaldisease in humans, including meningitis and puerperal sepsis. Structural formula of prontosil is  From the structure of prontosil, it is very clear that it has - N = N = - linkage. it was discovered that the part of the structure of protosil molecule shown in box, i.e., p-aminobenzenesuphonamide has antibacterial activity. Salvarsan is also known as arsphenamine. It was introduced at the begining of 1910s as the first effective treatment for syphills. t is an organosernic molecules and has -As = As- double bond.  Salvarsan and prontosil show similarity in their structure in their structure. Both of these drugs are antimicrobials. Salvarsan CONTAINS -As = As - linkage whereas prontosil has -N = N - linkage.  Prontosil (a red azo dye) and azo dye both have -N = N- linkage. 
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