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| 1. |
Show how you might synthesize 2-propanamine from a three-carbon starting material that is a ketone, aldehyde, nitrile, or amide. |
| Answer» Solution :We begin by recognizing that 2-propanamine has a primary AMINE group bonded to a secondary carbon. Neither a three-carbon nitrile nor a three-carbon amide can LEAD to this structural unit from a `C_(3)` starting material. An oxime can lead to the proper structure, but we must start with a three-carbon ketone rather than an aldehyde. THEREFORE, we choose PROPANONE as our starting material, convert it to an oxime, and then reduce the oxime to an amine. | |