I have been reading the other topics concerning this issue. I'm having a similar problem but with some twists. A few days ago my computer would not recognize either my CD-burner or CD-Rom drives, (E-drive & F-Drive). I checked in Bios and they were both listed & enabled but just would not run. I'm having a problem with the burner anyway and will be replacing it shortly , however, this is where it GETS weird. Yesterday, just for giggles, after starting up I went to My Computer and what do you know, both drives were listed. I checked the operation of the CD-Rom, everything worked perfectly. I restarted the computer so I could access Bios again, which I did. I usually have an operator password there to keep my kid out/off my machine. I installed the normal, operator password and continued with the boot-up. All booted up, etc. etc, went to My Computer, YIKES !! no E-drive or F-drive.. Again.
Well, I went back and removed the password thinking somehow that had something to do withn it. Needless to say, no change. So here I am back at square 1 where the machine does not recognize either drive. Each drive works mechanically, trays open, lights blink, etc. but will not respond to any installed disk, etc. I'm at a LOSS for what could be causing the problem. They don't even show up in the hardware list. NEED some advice / Help / tylenol.Are you sure you are free from malware?

Try totally disconnecting the slave drive and see if the master (whichever that is) works normally.Funny, Because I am Having that same exact problem. I have tried disconecting one, and conecting JEST the other one, and it still will not work. But about 2 days ago when I started up my pc one drive worked fine. I have been away from home for about 6 months and when I opened my case I noticed that it is really full of dust everywhere, could that be the problem? Also now when I start windows, I get the desktop backround fine, but I can't do anything, the mouse does not apear on the screen, even though it is plugged in fine, and I can't see the start menu or anything...really weird, could it be a Virus???
thanksI have been wondering the same thing....virus. I RAN my virus scans and even ran my spy ware software and nothing seemed to change. This is really beginning to be a pain and I would really appreciate some guidance.
Thank You