The only thing that CHANGED was I connected to a different monitor, installed a 2nd SSD and connected the motherboard speaker.

I tried disconnecting the speaker, 2nd SSD, and any USB ports. I also tried taking the CMOS battery out for 30 seconds. It gets stuck at the ASUS splash screen where it has the press Del or F2 at the bottom. It is the only thing I see. I can't even reinstall the UEFO/BIOS. I think it the latest version; it hasn't been updated too long ago.

Specs:
Motherboard: ASUS H110-A/M.2
RAM: 16GB DDR4 2133MHz 1.2V (x1)
Graphics: Integrated
Drives 1: SAMSUNG EVO 850 250GB M.2
Drive 2: Kingtech 60GB SSD/SATA (Disconnected)

~KamrynAre you getting any beeps or buzzes out of the speaker that you connected?I was getting one beep. It seemed to take longer then usual for the beep to start, maybe the computer is slower to start?I would suggest checking the connections from the PSU to the system, disconnect and reconnect each one - that will make sure that each one is SEATED properly.  Then try booting the PCI'm sorry for the delay in replying, I thought I already had.
It will eventually BOOT if I leave it for about 20 minutes.Try disconnecting the new SSD, see if it goes back to normal boot timesI found out the PROBLEM. I tried disconnecting everything, including the SATAs, which I thought I did before. The CD-ROM has gone faulty. I replaced it and it works now. I'm glad to hear that you got that sorted, good jobThank you for your help.