My mouse cursor is frozen on my desktop.  It will not move at all.  Previous to this the mouse cursor would move OK at times and would then lock up on the screen.  Now there is no movement.  I get the same effect when I start the computer in safemode.  Any IDEAS?Try another mouse.There are a few real nasty Bots  nad trojans that can create this situation, they basicly stop anyone trying to remove them.
Have you got (a) an Antivirus or (b) anti spyware or trojan remover tools. spybot s&d, Trojanguard, S&G,anything that can be run in safe mode.
Also do you KNOW how to run the computer solely from the keystrocks.
Sophos can supply a good set of removal tools for use from Floppies, http://www.sophos.com/support/knowledgebase/article/30.htmlVirus scanners
AVG Free
-- Anti virus scanner


Anti spy/MALWARE
Microsoft Antispyware
-- Anti spyware scanner. Windows XP Home and Professional only.
Spybot Search & Destroy
-- Anti spyware scanner
Adaware SE Personal
-- Anti spyware scanner

Firewalls
Using only one firewall is advised. Dual firewalls may cause problems.
Using a hardware firewall and a software firewall is even more adviced.
ZoneAlarm Free
-- Free firewall - more user friendly
Sygate Personal
-- Free firewall - more configuration options

Removal tools
The FOLLOWING files are not substitutes for the ones described above.
They are either diagnostic tools or removal tools for malware of a certain kind

HijackThis
-- Manual malware remover. Post the HijackThis log generated only if requested!
MCAFEE Stinger
-- Virus removal tool. No substitute for a fully functional virus scanner!
CWshredder
-- CoolWebSearch removal tool. Widely known and persistant Hijacker.