I am thinking of RUNNING a Raid on my System. I have never done one before but I know its not complex. My question is, which setup should i go with a 0+1 or 1+0 Raid. Main reason I wont go with a Raid 1 because, I want to insure I do not loose data just in case of FAILURE. But At the same time I looking for a increase in performance. Homework; http://en.wikipedia.org/wiki/RAID. The little chart halfway through should tell you what you want to know.

All hard disks are prone to failure. Your best bet is to Copy it to a CD/DVD. Twice. Store each disk in a nuclear shelter on both sides of the equator.

Ok, then there's the problem that DVDs might not hold data forever. So make sure those bunkers come with a statis field.

I know the general definition for both Raid setups already, what I am really asking (please excuse me for not clarifying what I am asking ) I want someone with knowledge using Raids, because I am looking for someone that has hands on experience with both raid 10 And 0+1 to tell me which raid gives overall better performance. How many hard drives do you have? Raid 0+1 or 1+0 require a minimum of 4 disks. If you're comparing Raid 0 vs. Raid 1, then I believe Raid 0 gives yields the best overall performance improvement, per http://m-techlaptops.com/raid.htm. But, Raid 1 also has a performance advantage over single, i.e. non-Raid, drive systems because it has Twice the Read transaction rate of single disks, but same Write transaction rate as single disks.
Well I am concerned about having a complete Updated backup of my data that is why i narrowed my choices to 10 or 0+1 , And yes I am going to be PURCHASING 4 Seagate 250 GB Drives Be sure to read the section on Nested levels in the link Raptor posted. I think the facts there will be your basis for deciding.