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The drug loading in resealed erythrocytes can be done by 1st immersing the cells in a buffered hypertonic solution.(a) True(b) FalseI got this question in semester exam.Origin of the question is Biopharmaceuticals in chapter Biopharmaceuticals of Drug Biotechnology

Answer»

Right answer is (B) False

Best explanation: No the CELLS have to be immersed in a hypotonic SOLUTION. The cells must be immersed in a buffered hypotonic solution of drug which causes these cells to RUPTURE and release hemoglobin and trap the medication. The RESTORATION can be done by the restoration of the isotonicity and incubating them at 37°C, the cells reseal and are ready to use.



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