1.

Triple test performed at 15-18 weeks of pregnancy. What is the positive test result indicate that the body having down syndrome?1. high and UE3 tend to be high that of MSAFP is low2. MSAFP and UE3 tend to be high that of hCG is low3. MSAFP and UE3 tend to be low that of hCG is high4. high and UE3 tend to be high that of MSAFP is high

Answer» Correct Answer - Option 3 : MSAFP and UE3 tend to be low that of hCG is high

Explanation

  • Down's syndrome is the commonest chromosome abnormality.
  • High maternity age is the major reason.
  • 1978-2010 incidence is increased up to 30%.

Screening

Second-trimester Screening Test.

  • AFP
  • E3
  • hCG

The triple test gives 70% accuracy.

  • Inhibin A is also tested and the test is known as the quadruple test.
  • Quadruple test reliability is up to 76%. 
DisorderMSAFPuE3Beta hCGInhibin A
Open NTDIncreasedNo changeNo changeNo change
Down's syndromeDecreasedDecreasedIncreasedIncreased
Trisomy 18DecreasedDecreasedNo changeNo change


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