What are the characteristics of colonic release systems?(a) Release the drug along the entire length of GIT(b) Prolonged their residence in the GIT and release(c) Usage of polymers that dissolves only in the alkaline pH of colon(d) Use of enteric coatingThe question was posed to me in a national level competition.My question is based upon Biopharmaceuticals in portion Biopharmaceuticals of Drug Biotechnology

What are the characteristics of colonic release systems?(a) Release th

1.	What are the characteristics of colonic release systems?(a) Release the drug along the entire length of GIT(b) Prolonged their residence in the GIT and release(c) Usage of polymers that dissolves only in the alkaline pH of colon(d) Use of enteric coatingThe question was posed to me in a national level competition.My question is based upon Biopharmaceuticals in portion Biopharmaceuticals of Drug Biotechnology
Answer» Correct choice is (C) Usage of polymers that dissolves only in the alkaline PH of COLON Explanation: For the drug to be released in colon pH sensitive bio erodible polymers like polymethacrylates are used. These polymers release the MEDICATION only at the alkaline pH of colon. These are used for the treatment of ulcerative colitis. Also can use divinylbenzene polymers which will be CLEAVED by azoreductase.

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