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What are the characteristics of diffusion-controlled release systems?(a) Release the drug along the entire length of GIT(b) Diffusion of the dissolved drug(c) Release only at a specific drug(d) Employ waxes to control the rate of dissolutionI have been asked this question at a job interview.I want to ask this question from Biopharmaceuticals in chapter Biopharmaceuticals of Drug Biotechnology

Answer»

Correct answer is (B) Diffusion of the dissolved drug

For explanation: The rate controlling step is the diffusion of the dissolved drug through a polymeric barrier. The drug release rate is never 0. The diffusional path length increases with TIME as the insoluble MATRIX gradually depletes from the drug. Two types of diffusion-controlled SYSTEMS are matrix systems and reservoir systems.



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