What are the characteristics of osmotic pressure-controlled systems?(a) Buffering agents that adjust pH to the desired value(b) Releases the drug at a zero-order kinetics(c) Hollow systems containing drug surrounded by a polymer membrane(d) Formation of complexes between the drug and anion/cation exchange resinsI have been asked this question during an interview.The question is from Biopharmaceuticals in chapter Biopharmaceuticals of Drug Biotechnology

What are the characteristics of osmotic pressure-controlled systems?(a

1.	What are the characteristics of osmotic pressure-controlled systems?(a) Buffering agents that adjust pH to the desired value(b) Releases the drug at a zero-order kinetics(c) Hollow systems containing drug surrounded by a polymer membrane(d) Formation of complexes between the drug and anion/cation exchange resinsI have been asked this question during an interview.The question is from Biopharmaceuticals in chapter Biopharmaceuticals of Drug Biotechnology
Answer» Right option is (b) Releases the drug at a zero-ORDER kinetics To explain I would say: Osmotic pressure-controlled systems works on the PRINCIPLE of osmotic pressure to release the drug at a constant zero order RATE. The core of the system comprises of the drug and osmotically active SUBSTANCE which will be surrounded by a rigid semipermeable membrane coating.

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