What are the characteristics of the mixed monolithic-reservoir devices?(a) The drug has a large therapeutic index(b) Drug permeation rate is high(c) The drug-polymer matrix is layered by rate-controlling membrane(d) Administration of emulsionsI got this question by my college professor while I was bunking the class.The above asked question is from Biopharmaceuticals topic in chapter Biopharmaceuticals of Drug Biotechnology

What are the characteristics of the mixed monolithic-reservoir devices

1.	What are the characteristics of the mixed monolithic-reservoir devices?(a) The drug has a large therapeutic index(b) Drug permeation rate is high(c) The drug-polymer matrix is layered by rate-controlling membrane(d) Administration of emulsionsI got this question by my college professor while I was bunking the class.The above asked question is from Biopharmaceuticals topic in chapter Biopharmaceuticals of Drug Biotechnology
Answer» Right answer is (c) The drug-polymer MATRIX is layered by rate-controlling membrane The explanation: This device has drug RELEASE KINETICS INTERMEDIATE between monolithic and reservoir systems. Here the drug-polymer matrix is layered by a rate controlling membrane. The release is CONTROLLED initially by the membrane but as the drug gets depleted the rate is controlled by diffusion of the drug.

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