What is the characteristic of pH-independent formulations?(a) Buffering agents that adjust pH to the desired value(b) Drug disperse in the insoluble matrix of rigid hydrophobic materials(c) Hollow systems containing drug surrounded by a polymer membrane(d) Formation of complexes between the drug and anion/cation exchange resinsThe question was posed to me in homework.My question is from Biopharmaceuticals topic in portion Biopharmaceuticals of Drug Biotechnology

What is the characteristic of pH-independent formulations?(a) Bufferin

1.	What is the characteristic of pH-independent formulations?(a) Buffering agents that adjust pH to the desired value(b) Drug disperse in the insoluble matrix of rigid hydrophobic materials(c) Hollow systems containing drug surrounded by a polymer membrane(d) Formation of complexes between the drug and anion/cation exchange resinsThe question was posed to me in homework.My question is from Biopharmaceuticals topic in portion Biopharmaceuticals of Drug Biotechnology
Answer» Correct answer is (a) BUFFERING agents that adjust pH to the desired value For EXPLANATION I would say: pH INDEPENDENT formulations are designed such that they can eliminate any changes in the drug property by the CHANGING GI pH. This is done by formulating them with sufficient amount of buffering agents such as phosphoric ACID, tartaric acid, citric acids. These formulations adjust the pH to the desired value.

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