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What is the site of action of the diuretic Acetazolamide?(a) Proximal tubule(b) Glomerulus(c) Descending loop of Henle(d) Distal tubuleI have been asked this question during an interview.My enquiry is from Diuretics in portion Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Answer»

Correct answer is (a) Proximal tubule

The BEST I can explain: Acetazolamide is carbonic anhydrase inhibitor, they work by inhibiting carbonic anhydrous, thus PREVENTS the exchange of H+ ions with sodium and water. The enzyme carbonic anhydrase helps to make H+ ions available so they can be exchanged with sodium and water in the proximal tubules. Inhibition of carbonic anhydrase reduces H+ ion CONCENTRATION in the RENAL tubule, as a result, there is increased excretion of bicarbonate, sodium, water, and potassium resorption of water is decreased and urine VOLUME is increased.



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