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Which of the following equations correct for Henderson-Hasselbach equation for weak acids?(a) PH = pKa – log (Unionized drug concentration /Ionized drug concentration)(b) PH = pKa – log (Ionized drug concentration/ Unionized drug concentration)(c) PH = pKa + log (Ionized drug concentration/ Unionized drug concentration)(d) PH = pKa + log (Unionized drug concentration /Ionized drug concentration)I had been asked this question in an international level competition.My question is taken from Drugs Absorption topic in chapter Absorption of Drugs of Drug Biotechnology

Answer»

The CORRECT OPTION is (c) PH = pKa + log (Ionized drug concentration/ Unionized drug concentration)

To EXPLAIN: For weak acids, the Henderson-Hasselbach EQUATION is pH = pKa + log (Ionized drug concentration/ Unionized drug concentration). And the % of ionized drug = 10pH-pHKa/1+10PH-pKa * 100.



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