Which of the following is true for monolithic devices?(a) These devices are used when the drug permeation rate is rapid(b) The release of the drug is controlled(c) Suitable for drugs with large therapeutic indices(d) The drug is contained in a powder form floating on liquidI have been asked this question in an internship interview.Enquiry is from Biopharmaceuticals in portion Biopharmaceuticals of Drug Biotechnology

Which of the following is true for monolithic devices?(a) These device

1.	Which of the following is true for monolithic devices?(a) These devices are used when the drug permeation rate is rapid(b) The release of the drug is controlled(c) Suitable for drugs with large therapeutic indices(d) The drug is contained in a powder form floating on liquidI have been asked this question in an internship interview.Enquiry is from Biopharmaceuticals in portion Biopharmaceuticals of Drug Biotechnology
Answer» RIGHT answer is (c) SUITABLE for drugs with large therapeutic indices For explanation I would say: The DRUG used in these devices has a large therapeutic index. The drug release rate from the matrix is RAPID initially and then falls as the matrix gets depleted of the drug. The polymer employed for the matrix system may be hydrophilic or LIPOPHILIC. These polymers include PVC, PVP, and polysaccharides.

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