1.

Write the mechanisms and applications(a) Mannich reaction

Answer»

TheMannich reactionis anorganic reactionwhich consists of anamino alkylationof an acidic proton placed next to acarbonylfunctional groupbyformaldehydeand a primary or secondaryamineorammonia. The final product is a β-amino-carbonyl compound also known as aMannich base.Reactions betweenaldiminesand α-methylene carbonyls are also considered Mannich reactions because these imines form between amines and aldehydes. The reaction is named afterchemistCarl Mannich.



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