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TLC is USED to check WHEATHER the REACTION is completed or not. HPLC is used to identify, quantify,and for SEPARATION of mixture.

TLC is used to check wheather the reaction is completed or not. HPLC is used to identify, quantify,and for separation of mixture.

CONTAMINATION in CALIBRATION STANDARDS during the TKN DIGESTION.

Contamination in calibration standards during the TKN digestion.

Since it is performed as PER ICH GUIDELINES for validation.

Since it is performed as per ICH guidelines for validation.

The VOLUME from GPV to DETECTOR.

The volume from gpv to detector.

it is having both REGULATORY and DOMESTIC MARKETS.

it is having both regulatory and domestic markets.

calibration is also one of the SYSTEM suitability test,whether the system working satisfactory or not physically so when you do the calibration for pH meter with standard pH buffer solution (which is from NIST-it may ACCURATE solution for actual pH)and once if your instrument has calibrated,you can cross VERIFY your insrument against those pH buffer solution (NIST) and the ACCEPTABLE range is +/- 0.02 then you can conclude for. once if temperature raises the pH will DECREASE and its not all cases.

calibration is also one of the system suitability test,whether the system working satisfactory or not physically so when you do the calibration for pH meter with standard pH buffer solution (which is from NIST-it may accurate solution for actual pH)and once if your instrument has calibrated,you can cross verify your insrument against those pH buffer solution (NIST) and the acceptable range is +/- 0.02 then you can conclude for. once if temperature raises the pH will decrease and its not all cases.

5 MG of water CONSUMING 1 ml of KF reagent.

5 mg of water consuming 1 ml of KF reagent.

C8 COLUMN have more POLAR than C18. and it has 8 CARBON ATOMS.

C8 column have more polar than C18. and it has 8 carbon atoms.

• Purity is only area NORMALIZATION.
• RS is calculated by USING std and RRF.

In the GAS chromatography, nitrogen gas is USED CARRIER gas and make up gas.

In the gas chromatography, nitrogen gas is used carrier gas and make up gas.

When analyte gives linear RESPONSE then only we can USE area normalization. When analyte response is to high and saturated in chromatograph, for this CONDITION we can use DILUTED standard.

When analyte gives linear response then only we can use area normalization. When analyte response is to high and saturated in chromatograph, for this condition we can use diluted standard.

No, We will not dry DST before FACTOR DETERMINATION by USING karl FISHER titrator.

No, We will not dry dst before factor determination by using karl fisher titrator.

KF titration is the most accurate method in analysing MOISTURE content. But it is coastlier and maintaince is too high. So in analysis of moisture content an alternative experiment is Loss on Drying(LOD), which GIVES approximate moisture value PRESENT in the given substance.

KF titration is the most accurate method in analysing moisture content. But it is coastlier and maintaince is too high. So in analysis of moisture content an alternative experiment is Loss on Drying(LOD), which gives approximate moisture value present in the given substance.

quality control means to MAINTAIN the quality of product by calculating their content ,different physical parameters,as PER their SPECIFICATION IP/BP/USP/EP/JP.

quality control means to maintain the quality of product by calculating their content ,different physical parameters,as per their specification IP/BP/USP/EP/JP.

ACN is highly polar as COMPARE to METHANOL So provide Better RESOLUTION for MANY compound and it has property to FORM hydrogen bond so provide better selectivity.

ACN is highly polar as compare to Methanol So provide Better resolution for many compound and it has property to form hydrogen bond so provide better selectivity.

CHECK for the number of PLATES that it MAINTAINS stady all over the run , check the SST at AVERY run that cpmplies the ACCEPTANCE criterias of the method.

Check for the number of plates that it maintains stady all over the run , check the SST at avery run that cpmplies the acceptance criterias of the method.

ISOTOPES of H2O, D2O.

Isotopes of H2O, D2O.

Tlc is called THIN LAYER chromatography. The simple TECHNIQUE works on the PRINCIPLE of ADSORPTION, where as HPLC is a sophisticated technique works on partition principle.

Tlc is called thin layer chromatography. The simple technique works on the principle of adsorption, where as HPLC is a sophisticated technique works on partition principle.

RS stands for related substance, means by-products upon completion of reaction, or the unreacted PORTION present in the PRODUCT. RS TESTING help us to identify the adequate quantitiy of these by-products or unreacted part. More over RS help us during the stability study to KNOW any significant CHANGE in the nature of product during long storage in various climatic conditions

RS stands for related substance, means by-products upon completion of reaction, or the unreacted portion present in the product. RS testing help us to identify the adequate quantitiy of these by-products or unreacted part. More over RS help us during the stability study to know any significant change in the nature of product during long storage in various climatic conditions

PH of the buffer solution will be change, as due to presence of nitrogen containing substances and also due to microbial GROWTH. but if stored at 4 degree CENTI. it may used to some EXTENT.

PH of the buffer solution will be change, as due to presence of nitrogen containing substances and also due to microbial growth. but if stored at 4 degree centi. it may used to some extent.

If all impurtities at spec LEVEL are meeting s/n ratio more than 60 at that particular concentration as WEL as no COLUMN overload.

If all impurtities at spec level are meeting s/n ratio more than 60 at that particular concentration as wel as no column overload.

Reference std is like USP,EP std , in this std we get COA including results of Potency by HPLC , NMR & XRPD DATA. whenever there is requirement of w.std preparation first we have get API rawmaterial from warehouse & we CHECK assay , WATER content or LOD & Related SUBSTANCES aganist reference std . Some times we are doing analysis in duplicate & get mean value.then we decide FINAL assay or potency value & it's validity one year

Reference std is like USP,EP std , in this std we get COA including results of Potency by HPLC , NMR & XRPD data. whenever there is requirement of w.std preparation first we have get API rawmaterial from warehouse & we check assay , water content or LOD & Related substances aganist reference std . Some times we are doing analysis in duplicate & get mean value.then we decide final assay or potency value & it's validity one year

• Base line is nothing but the detectors response to the mobile phase.(gc,hplc) 
• Base line should be stable to start a run. 
• Un STABILIZED base line is called as base line noise. 
• Base line noise is of many TYPES.. 
• Cyclic base line 
• Synchorinise noise 
• Asynchorinise noise 
• Base line drift 
• Spikes 
• Negative peaks 
• No peaks
• Base line noise is ATTRIBUTED due to mobile phase,sample, system problems.leaks in the system,temperature variations in LAB etc..

The chemical substances that pair each other, to form COMPLEXES. These can USE for STABILIZATION of one of the molecule that is more ACTIVE or to colorifying etc.

The chemical substances that pair each other, to form complexes. These can use for stabilization of one of the molecule that is more active or to colorifying etc.

The H is the HEIGHT of the MAIN peak and the h is the lowest height of a peak in the range of X5 the main peak (around the amin peak).

The H is the height of the main peak and the h is the lowest height of a peak in the range of X5 the main peak (around the amin peak).

Standard deviation tells about the widely SPREAD out of the MEASURED analytical DATA POINTS. Highly precised measurements are less standard deviation.

Standard deviation tells about the widely spread out of the measured analytical data points. Highly precised measurements are less standard deviation.