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InterviewSolution
This section includes InterviewSolutions, each offering curated multiple-choice questions to sharpen your knowledge and support exam preparation. Choose a topic below to get started.
| 51. |
Which of the following is the commonly used support material for the packed column in gas chromatography?(a) Glass(b) Metal(c) Diatomaceous earth(d) Stainless steelI have been asked this question by my college director while I was bunking the class.I'm obligated to ask this question of Gas Chromatography topic in division Chromatography of Analytical Instrumentation |
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Answer» The correct answer is (c) Diatomaceous EARTH |
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| 52. |
Which of the following is not an advantage for the conversion of packed columns into wide bore capillaries?(a) Longer retention times(b) Longer life(c) Higher efficiency(d) Greater inertnessThe question was posed to me by my college director while I was bunking the class.My doubt stems from Gas Solid Chromatography topic in portion Chromatography of Analytical Instrumentation |
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Answer» Right answer is (a) LONGER retention times |
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| 53. |
What must be the value of the selectivity factor?(a) Equal to 1(b) Less than 1(c) Greater than 1(d) Greater than 0This question was posed to me in an online interview.My query is from Chromatographic Behaviour of Solutes topic in division Chromatography of Analytical Instrumentation |
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Answer» Right option is (c) Greater than 1 |
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| 54. |
Which of the following is the distance that the solute moves while undergoing one partition?(a) Retention distance(b) Distribution constant(c) Plate height(d) Column packing lengthThe question was posed to me during an online exam.My question comes from Column Efficiency and Column Resolution topic in section Chromatography of Analytical Instrumentation |
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Answer» CORRECT CHOICE is (c) PLATE height To EXPLAIN: Plate height is the distance that the solute moves while undergoing ONE partition. It is expressed in length. |
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| 55. |
In gas-liquid chromatography, when films are used in the interior of the capillary column, then what is the value of Eddy diffusion?(a) Greater than 1(b) Less than 1(c) Zero(d) Less than zeroThe question was posed to me in an internship interview.Origin of the question is Column Efficiency and Column Resolution topic in chapter Chromatography of Analytical Instrumentation |
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Answer» The correct OPTION is (c) ZERO |
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| 56. |
Which of the following is the disadvantage of reciprocating pump used in liquid chromatography?(a) Produces pulsed flow(b) Corrosive components(c) Does not have small hold-up value(d) Does not have moderate flow rateI got this question in unit test.My doubt is from Liquid Chromatography in section Chromatography of Analytical Instrumentation |
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Answer» The CORRECT choice is (a) PRODUCES pulsed flow |
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| 57. |
Which of the following is not the advantage of thermal conductivity detector used in gas chromatography?(a) Simple in construction(b) High sensitivity(c) Large linear dynamic range(d) Non-destructive characterI have been asked this question in an online quiz.My enquiry is from Detection System of Gas Chromatography in portion Chromatography of Analytical Instrumentation |
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Answer» Right CHOICE is (b) HIGH sensitivity |
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| 58. |
In Automatic amino-acid analyzer, the sample containing ___________ of each amino compound is introduced at the top of the ion exchange column.(a) 1 to 10 µmoles(b) 1 to 10 moles(c) 0.05 to 2 moles(d) 0.05 to 2 µmolesI have been asked this question by my school principal while I was bunking the class.My query is from Amino-Acid Analysers topic in chapter Chromatography of Analytical Instrumentation |
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Answer» RIGHT answer is (d) 0.05 to 2 µmoles For EXPLANATION: In Automatic amino-acid analyzer, the sample having 0.05 to 2 µmoles of each amino compound is introduced at the top of the ion EXCHANGE column. Buffer is then SUPPLIED to the column. |
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| 59. |
High pressure liquid chromatography can be performed only in columns.(a) True(b) FalseThis question was addressed to me in unit test.I'd like to ask this question from High Pressure Liquid Chromatography in chapter Chromatography of Analytical Instrumentation |
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Answer» Correct option is (a) True |
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| 60. |
Which of the following is not a feature of carrier gas used in gas chromatography?(a) It must be chemically inert(b) It should be suitable for the detector employed(c) It should not be completely pure(d) It should be cheapThe question was asked in homework.My enquiry is from Gas Chromatography topic in chapter Chromatography of Analytical Instrumentation |
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Answer» Right choice is (c) It should not be COMPLETELY PURE |
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| 61. |
Which of the following will improve the efficiency of the separation process in liquid chromatography?(a) Increase in sample size, increase in column diameter(b) Reduction in sample size, increase in column diameter(c) Increase in sample size, reduction in column diameter(d) Reduction in sample size, reduction in column diameterThe question was asked during an online interview.This intriguing question originated from Liquid Chromatography topic in portion Chromatography of Analytical Instrumentation |
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Answer» Correct choice is (d) Reduction in SAMPLE size, reduction in COLUMN diameter |
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| 62. |
Which of the following pulse damper takes up some amount of the pulsation energy which is released to provide smooth pressure without pulsations?(a) Flexible bellows or compressible gas passed through tee columns(b) Flexible inert diaphragm(c) Electronic pulse damper(d) Electrical pulse damperThis question was addressed to me in homework.The doubt is from High Pressure Liquid Chromatography topic in portion Chromatography of Analytical Instrumentation |
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Answer» Correct choice is (a) Flexible bellows or compressible gas passed through tee columns |
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| 63. |
Which of the following colour reagents are used in Resin column chromatography?(a) Marquis reagent(b) Benedict reagent(c) Ninhydrin(d) Nessler’s reagentI had been asked this question during an interview.This intriguing question originated from Amino-Acid Analysers in section Chromatography of Analytical Instrumentation |
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Answer» The correct choice is (d) Nessler’s reagent |
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| 64. |
Resin column chromatography does not involve breaking of bonds in amino-acids.(a) True(b) FalseThe question was asked in examination.I want to ask this question from Amino-Acid Analysers in section Chromatography of Analytical Instrumentation |
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Answer» The correct choice is (b) False |
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| 65. |
It is more difficult to measure the width at half peak height than the base width in the detector output.(a) True(b) FalseI had been asked this question in an online quiz.Question is from Column Efficiency and Column Resolution topic in section Chromatography of Analytical Instrumentation |
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Answer» Correct option is (b) False |
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| 66. |
Flame ionisation detector is also known as Katharometer.(a) True(b) FalseI got this question in final exam.My doubt stems from Detection System of Gas Chromatography in section Chromatography of Analytical Instrumentation |
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Answer» Right OPTION is (b) False |
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| 67. |
Which of the following is the advantage of a straight packed column?(a) It can be packed uniformly(b) It can be repacked easily(c) It is compact(d) It is easier to heat it evenlyI had been asked this question during an internship interview.My query is from Gas Chromatography topic in section Chromatography of Analytical Instrumentation |
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Answer» Right answer is (c) It is COMPACT |
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| 68. |
Detector selectivity is more important in Liquid chromatography than in Gas chromatography.(a) True(b) FalseThis question was posed to me in an interview for internship.My question is taken from Detection System of Liquid Chromatography topic in section Chromatography of Analytical Instrumentation |
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Answer» The CORRECT answer is (a) True |
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| 69. |
What is the drawback that occurs in using ion exchange chromatography on sulphonated polystyrene resin and colourimetry for amino-acid analysis?(a) Less accuracy(b) Low resolution(c) Inconvenient to handle many individual samples(d) Slow in operationThis question was addressed to me in an internship interview.This intriguing question originated from Amino-Acid Analysers topic in chapter Chromatography of Analytical Instrumentation |
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Answer» RIGHT option is (c) Inconvenient to handle many INDIVIDUAL samples The explanation: When ion exchange chromatography is used for amino-acid ANALYSIS, high ACCURACY is obtained. It is inconvenient to handle many individual samples and cleaning of glassware is laborious. |
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| 70. |
The solute, while moving in the column is always in equilibrium with both the stationary phase and the mobile phase.(a) True(b) FalseI have been asked this question in an interview for job.Origin of the question is Column Efficiency and Column Resolution in chapter Chromatography of Analytical Instrumentation |
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Answer» Correct OPTION is (a) True |
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| 71. |
Which of the following is the ratio of the interstitial volume of packing to the volume of its total mass?(a) Distribution constant(b) Volumetric phase ratio(c) Retention factor(d) Total porosityI had been asked this question during an interview.Query is from Chromatographic Behaviour of Solutes in section Chromatography of Analytical Instrumentation |
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Answer» CORRECT CHOICE is (d) Total porosity For EXPLANATION: Total porosity is the ratio of the interstitial volume of packing to the volume of its total mass. In a capillary column, total porosity is 1. |
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| 72. |
Which of the following is the disadvantage of nitrogen, which can be used as carrier gas in gas chromatography?(a) Dangerous to use(b) Expensive(c) Reduced sensitivity(d) High densityThe question was asked during an interview.This intriguing question comes from Gas Chromatography in chapter Chromatography of Analytical Instrumentation |
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Answer» CORRECT option is (C) Reduced sensitivity For explanation I would say: Nitrogen has reduced sensitivity. It is still one of the commonly USED carrier gas in gas chromatography. |
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| 73. |
Which of the following is not an advantage of Syringe type pumps used in High pressure liquid chromatography?(a) Independent of viscosity(b) Pulse-less flow(c) High pressure capability(d) Unlimited solvent capacityThe question was posed to me in an interview.This key question is from High Pressure Liquid Chromatography in chapter Chromatography of Analytical Instrumentation |
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Answer» The correct CHOICE is (d) UNLIMITED solvent capacity |
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| 74. |
Which of the following is not true about the radial compression column when compared to standard separation column?(a) Internal diameter decreases(b) Overall operating pressure decreases(c) Analysis time decreases(d) Solvent flow increasesThe question was asked by my school principal while I was bunking the class.My question is based upon Liquid Chromatography topic in portion Chromatography of Analytical Instrumentation |
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Answer» Right CHOICE is (a) Internal diameter decreases |
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| 75. |
Which of the following is not true about solvent programming which is done in high performance liquid chromatography?(a) It provides unequal bandwidths(b) It provides fast overall separation(c) It provides maximum resolution(d) It provides maximum sensitivityThe question was posed to me during an interview.My question comes from High Pressure Liquid Chromatography in section Chromatography of Analytical Instrumentation |
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Answer» Right option is (a) It provides unequal bandwidths |
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| 76. |
Which of the following cannot be done to reduce ripple in High pressure liquid chromatography?(a) Using bellows(b) Using restrictors(c) Using long nylon tube between pump and column(d) Avoiding the use of the solvent pumpI had been asked this question in an international level competition.I'm obligated to ask this question of High Pressure Liquid Chromatography topic in chapter Chromatography of Analytical Instrumentation |
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Answer» Correct option is (d) Avoiding the use of the solvent pump |
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| 77. |
The reference cell is packed with which of the following in the Adsorption detector used in liquid chromatography?(a) Inactive glass beads(b) Porous glass beads(c) Alumina(d) SilicaThis question was posed to me in a national level competition.My enquiry is from Detection System of Liquid Chromatography in portion Chromatography of Analytical Instrumentation |
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Answer» Correct ANSWER is (a) INACTIVE glass beads |
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| 78. |
Which of the following is not a feature of refractive index type detectors?(a) Higher potential sensitivity(b) Low cost(c) High volume flow rates(d) Easy cell accessibilityI had been asked this question at a job interview.I'm obligated to ask this question of Detection System of Liquid Chromatography in division Chromatography of Analytical Instrumentation |
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Answer» RIGHT option is (c) HIGH volume flow RATES For explanation I would say: Refractive index TYPE detectors have low volume flow rates. It is one of the MAJOR advantages of the refractive index type of detectors. |
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| 79. |
Which of the following cannot be analysed using resin column chromatography?(a) Peptides(b) Amines(c) Amino compounds(d) Components which are ninhydrin negativeThis question was posed to me by my school principal while I was bunking the class.I would like to ask this question from Amino-Acid Analysers in portion Chromatography of Analytical Instrumentation |
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Answer» Right CHOICE is (d) Components which are ninhydrin negative |
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| 80. |
Capillary columns are open tubular columns constructed from which of the following materials?(a) Glass(b) Metal(c) Stainless steel(d) Fused silicaThis question was posed to me in quiz.Question is taken from Gas Chromatography topic in division Chromatography of Analytical Instrumentation |
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Answer» Correct OPTION is (d) FUSED silica |
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| 81. |
Which of the following detectors have high sensitivity to all organic compounds?(a) Sulphur chemiluminescense detector(b) Thermionic emission detector(c) Flame ionization detector(d) Argon ionisation detectorThis question was addressed to me in an international level competition.My question is from Detection System of Gas Chromatography in portion Chromatography of Analytical Instrumentation |
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Answer» Right choice is (c) Flame IONIZATION DETECTOR |
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| 82. |
Which of the following is not a characteristic of the syringe pump used in high pressure liquid chromatography?(a) Pressure capability is high(b) Maintenance is frequent(c) Limited reservoir capability(d) Slight change of flow rate when extremely high pressure compresses the solventI got this question during an interview.I need to ask this question from High Pressure Liquid Chromatography in division Chromatography of Analytical Instrumentation |
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Answer» CORRECT OPTION is (b) MAINTENANCE is frequent The BEST EXPLANATION: In syringe pumps, maintenance is infrequent. However, it has high pressure capability. |
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| 83. |
Gravity feed method for solvent delivery is not used with narrow bore columns packed with fine mesh particles.(a) True(b) FalseThis question was addressed to me in semester exam.The above asked question is from High Pressure Liquid Chromatography topic in chapter Chromatography of Analytical Instrumentation |
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Answer» Right ANSWER is (a) True |
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| 84. |
Which of the following is true about Laser detectors used in liquid chromatography?(a) Causes thermal distortion has decreased sensitivity(b) Causes thermal distortion has increased sensitivity(c) Does not cause thermal distortion, has decreased sensitivity(d) Does not cause thermal distortion, has increased sensitivityThis question was addressed to me in an online interview.The above asked question is from Detection System of Liquid Chromatography in portion Chromatography of Analytical Instrumentation |
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Answer» RIGHT answer is (a) Causes THERMAL distortion has decreased SENSITIVITY For explanation: LASER detectors USED in liquid chromatography cause thermal distortion and have decreased sensitivity. This is because of the high energies of a laser. |
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| 85. |
Adjusted retention volume is the remaining retention volume after subtracting ___________ from _____________(a) Solute migration rate and retention volume(b) Retention volume and solute migration rate(c) Dead volume and retention volume(d) Retention volume and dead volumeI got this question in an online quiz.This is a very interesting question from Chromatographic Behaviour of Solutes in chapter Chromatography of Analytical Instrumentation |
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Answer» Correct choice is (c) DEAD volume and retention volume |
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| 86. |
Retention volume can be obtained by finding the product of which of the following parameters?(a) Dead time and total porosity(b) Retention time and volumetric flow rate(c) Adjusted retention time and volumetric flow rate(d) Retention time and total porosity.The question was asked in homework.The query is from Chromatographic Behaviour of Solutes in chapter Chromatography of Analytical Instrumentation |
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Answer» Correct CHOICE is (b) Retention time and VOLUMETRIC flow rate |
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| 87. |
Which of the following is not a type of detector used in gas chromatography?(a) Argon ionisation detector(b) Thermal conductivity detector(c) UV visible spectrometric detector(d) Electron capture detectorI got this question in examination.I need to ask this question from Detection System of Gas Chromatography in section Chromatography of Analytical Instrumentation |
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Answer» Right option is (c) UV VISIBLE spectrometric DETECTOR |
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| 88. |
Base line resolution is achieved when degree of resolution/separation is ______(a) 1(b) 0(c) 0.5(d) 1.5I got this question in an internship interview.This interesting question is from Column Efficiency and Column Resolution in section Chromatography of Analytical Instrumentation |
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Answer» The correct CHOICE is (d) 1.5 |
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| 89. |
Which of the following detectors is widely used to detect environmental samples like chlorinated pesticides and polychlorinated biphenyls?(a) Flame ionization detector(b) Thermal conductivity detector(c) Argon ionisation detector(d) Electron capture detectorThis question was addressed to me in class test.Enquiry is from Detection System of Gas Chromatography topic in portion Chromatography of Analytical Instrumentation |
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Answer» Right answer is (d) Electron capture detector |
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| 90. |
Which of the following detectors used in liquid chromatography is also called micro-adsorption detector?(a) Electrochemical detectors(b) Fluorescence detectors(c) Refractive index detectors(d) Thermal detectorsI got this question by my college director while I was bunking the class.My question comes from Detection System of Liquid Chromatography in division Chromatography of Analytical Instrumentation |
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Answer» Right ANSWER is (d) Thermal detectors |
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| 91. |
Which of the following properties of molecular sieves make it ideal for exclusion mechanism of separation?(a) High thermal stability(b) Large inner surface area(c) Variable framework charge(d) Ability to distinguish materials on the basis of their sizeThis question was posed to me by my school principal while I was bunking the class.This intriguing question comes from Gas Solid Chromatography topic in section Chromatography of Analytical Instrumentation |
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Answer» Right choice is (d) Ability to DISTINGUISH materials on the basis of their SIZE |
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| 92. |
Which of the following equations give the expression for plate number, N when ‘tR’ is the adjusted retention time and ‘Wb’ is the width at the base of the peak which is equal to 4 standard deviations.(a) 16 tR^2/Wb(b) 4 tR^2/Wb(c) (4tR/Wb)^2(d) 4 (tR/Wb)^2I had been asked this question at a job interview.My question is taken from Column Efficiency and Column Resolution topic in section Chromatography of Analytical Instrumentation |
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Answer» The CORRECT answer is (c) (4tR/Wb)^2 |
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| 93. |
Which of the following is the disadvantage of coiled or helical shaped packed chromatographic column?(a) It cannot be packed uniformly(b) It cannot be repacked easily(c) It is not compact(d) It is not easy to heat it evenlyI have been asked this question in my homework.This intriguing question comes from Gas Chromatography in section Chromatography of Analytical Instrumentation |
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Answer» Right ANSWER is (b) It cannot be repacked easily |
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| 94. |
For the separation of which of the following substances, Gas-solid chromatography is being used?(a) Thermally stable organic components(b) Volatile organic components(c) Thermally stable inorganic components(d) Low molecular weight gaseous speciesI have been asked this question by my college professor while I was bunking the class.Query is from Gas Chromatography topic in chapter Chromatography of Analytical Instrumentation |
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Answer» Right option is (d) LOW molecular WEIGHT gaseous SPECIES |
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| 95. |
Which of the following is not a Column-type Liquid chromatography?(a) Gel permeation(b) Ion exchange(c) Liquid-solid(d) PaperThe question was asked at a job interview.I need to ask this question from Liquid Chromatography topic in portion Chromatography of Analytical Instrumentation |
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Answer» The CORRECT answer is (d) PAPER |
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| 96. |
Which of the following types of liquid chromatography uses immobilized biochemical as a stationary phase?(a) Ion exchange chromatography(b) Exclusion chromatography(c) Affinity chromatography(d) Gel permeation chromatographyThis question was posed to me in homework.My doubt is from Liquid Chromatography in section Chromatography of Analytical Instrumentation |
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Answer» Correct OPTION is (C) Affinity chromatography |
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| 97. |
Which of the following is not true about Hydraulic capacitance flow control system used in HPLC?(a) It can be used only for liquids with low viscosity(b) It is irrespective of solvent compressibility(c) It maintains a constant flow(d) It smoothens high pressure pump pulsationsI had been asked this question in an online interview.Enquiry is from High Pressure Liquid Chromatography topic in chapter Chromatography of Analytical Instrumentation |
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Answer» The CORRECT ANSWER is (a) It can be used only for liquids with low viscosity |
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| 98. |
Which of the following is not a property of a good detector used in liquid chromatography?(a) Good sensitivity(b) Ability to function in the presence of a large background signal(c) Short response time(d) Volume of detector must be largeI got this question in a job interview.I'd like to ask this question from Detection System of Liquid Chromatography in division Chromatography of Analytical Instrumentation |
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Answer» The correct ANSWER is (d) Volume of DETECTOR must be large |
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| 99. |
Fluorescence detection is less selective than absorption detection.(a) True(b) FalseI got this question during an interview.My doubt stems from Detection System of Liquid Chromatography topic in section Chromatography of Analytical Instrumentation |
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Answer» CORRECT ANSWER is (b) False To EXPLAIN: Fluorescence detection is more selective than absorption detection. This is because of its high sensitivity. |
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| 100. |
Which of the following is defined as the ratio of moles of solute in stationary phase to the moles of solute in the mobile phase?(a) Distribution constant(b) Volumetric phase ratio(c) Retention factor(d) Total porosityThe question was posed to me in an interview.The origin of the question is Chromatographic Behaviour of Solutes in chapter Chromatography of Analytical Instrumentation |
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Answer» Correct choice is (c) Retention factor |
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