InterviewSolution
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InterviewSolution
This section includes InterviewSolutions, each offering curated multiple-choice questions to sharpen your knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Which of the following involves carrying genetic information from DNA for protein synthesis?(a) m-RNA(b) t-RNA(c) r-RNA(d) sn-RNAThe question was posed to me in an international level competition.Origin of the question is Nucleic Acid Chemistry in section Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Right ANSWER is (a) m-RNA |
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| 2. |
Which of the following is false about purine and pyrimidine bases?(a) They are hydrophobic and relatively insoluble in water at the near-neutral pH of the cell(b) At acidic or alkaline pH the bases become charged and their solubility in water increases(c) Purines have two rings in their structure, but pyrimidine bases have only one ring(d) At acidic or alkaline pH the bases become charged and their solubility in water decreasesThis question was addressed to me in homework.I need to ask this question from Nucleotides & Nucleic Acids Basics in portion Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Correct answer is (d) At acidic or alkaline PH the BASES BECOME charged and their SOLUBILITY in water decreases |
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| 3. |
What is the composition of nucleoside?(a) a sugar + a phosphate(b) a base + a sugar(c) a base + a phosphate(d) a base + a sugar +phosphateThe question was asked in unit test.My doubt is from Nucleotides & Nucleic Acids Basics in section Nucleotides and Nucleic Acids of Biochemistry |
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Answer» The correct ANSWER is (B) a base + a SUGAR |
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| 4. |
Which of the following is false?(a) The stability of an RNA-DNA hybrid is generally intermediate between that of RNA and DNA(b) RNA duplexes are more stable than DNA duplexes(c) DNA duplexes are more stable than RNA duplexes(d) DNA duplexes are less stable than RNA- DNA hybridThe question was posed to me in homework.Asked question is from Nucleic Acid Chemistry topic in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Correct CHOICE is (C) DNA duplexes are more stable than RNA duplexes |
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| 5. |
What happens in hyperchromicity?(a) When DNA is in bound form, there is decrease in absorption of UV light(b) When DNA is in bound form, there is increase in absorption of UV light(c) When DNA is in unbound form, it is more stable(d) When DNA is in unbound form, there is increase in absorption of UV lightThis question was addressed to me by my school teacher while I was bunking the class.I need to ask this question from Nucleic Acid Chemistry in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Correct ANSWER is (d) When DNA is in UNBOUND form, there is increase in absorption of UV LIGHT |
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| 6. |
Which of the following is true about tm?(a) It can be termed as renaturation temperature(b) The higher the content of G ≡ C base pairs, the higher the tm(c) The higher the content of A = T base pairs, the higher the tm(d) The higher the content of G ≡ C base pairs, the lower the tmThe question was asked at a job interview.My question is from Nucleic Acid Chemistry topic in portion Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Right choice is (b) The higher the content of G ≡ C BASE PAIRS, the higher the TM |
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| 7. |
Which of the following statements is true?(a) Sugar component of a nucleotide is ribose(b) Sugar component of a nucleotide is deoxyribose(c) The bases in nucleotides are attached to a pentose sugar moiety by a glycosidic linkage(d) The sugar molecule of the nucleotide is in L-configurationThis question was addressed to me in an internship interview.This question is from Nucleotides & Nucleic Acids Basics in division Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Right OPTION is (c) The bases in nucleotides are ATTACHED to a pentose sugar moiety by a GLYCOSIDIC linkage |
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| 8. |
The sugar molecule in a nucleotide is ____________(a) Pentose(b) Hexose(c) Tetrose(d) TrioseI got this question in an interview for job.The query is from Nucleotides & Nucleic Acids Basics topic in division Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Right choice is (a) Pentose |
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| 9. |
Identify the purine base of nucleic acids in the following.(a) Cytosine(b) Thymine(c) Uracil(d) AdenineI got this question in quiz.This is a very interesting question from Nucleotides & Nucleic Acids Basics in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Right CHOICE is (d) Adenine |
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| 10. |
What is the composition of nucleotide?(a) a sugar + a phosphate(b) a base + a sugar(c) a base + a phosphate(d) a base + a sugar +phosphateThis question was posed to me in semester exam.This key question is from Nucleotides & Nucleic Acids Basics in division Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Correct answer is (d) a base + a SUGAR +PHOSPHATE |
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| 11. |
Which ratio is constant for DNA?(a) A + G / T + C(b) A + T / G + C(c) A + C / U + G(d) A + U / G + CThis question was posed to me in a national level competition.The above asked question is from Nucleic Acid Structure topic in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» RIGHT CHOICE is (a) A + G / T + C Explanation: The MOLAR CONCENTRATION of purine bases A and G is equal to the molar concentration of PYRIMIDINE bases T and C because one of each type makes up a base pair. Because of base pairing rules, A = T and G = C. The specific A – T and G – C content varies from species to species. But in any one species the ratio is constant. |
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| 12. |
Which of the following nucleotides is not present in RNA?(a) AMP(b) GMP(c) CMP(d) TMPThis question was posed to me during an interview.I would like to ask this question from Nucleic Acid Chemistry in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» The CORRECT OPTION is (d) TMP |
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| 13. |
Number of hydrogen bonds between guanine and cytosine?(a) 1(b) 2(c) 3(d) 4I have been asked this question in my homework.My query is from Nucleic Acid Structure in division Nucleotides and Nucleic Acids of Biochemistry |
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Answer» RIGHT OPTION is (c) 3 Explanation: G≡C is the NOTATION for BONDING between G and C. |
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| 14. |
Which of the following is true about phosphodiester linkage?(a) 5’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide(b) 3’-phosphate group of one nucleotide unit is joined to the 5’-hydroxyl group of the next nucleotide(c) 5’-phosphate group of one nucleotide unit is joined to the 5’-hydroxyl group of the next nucleotide(d) 3’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotideI got this question in examination.The question is from Nucleotides & Nucleic Acids Basics topic in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» RIGHT OPTION is (a) 5’-phosphate group of one NUCLEOTIDE UNIT is joined to the 3’-hydroxyl group of the next nucleotide For explanation: 5’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide. |
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| 15. |
Which of the following is false?(a) RNA does not obey Chargaff’s rule(b) DNAs can be identified by Orcinol color reaction(c) In RNA OH group is present at 2’ position(d) Alkali hydrolyses RNA to 2’3’-cyclic diestersI have been asked this question in an international level competition.Asked question is from Nucleic Acid Chemistry in division Nucleotides and Nucleic Acids of Biochemistry |
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Answer» CORRECT choice is (B) DNAs can be identified by Orcinol COLOR reaction The BEST explanation: RNAs can be identified by Orcinol color reaction. |
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| 16. |
Which of the following nucleotides is not present in DNA?(a) AMP(b) GMP(c) CMP(d) UMPThe question was posed to me during an internship interview.This interesting question is from Nucleic Acid Chemistry in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» The CORRECT CHOICE is (d) UMP |
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| 17. |
Building blocks of nucleic acids are ____________(a) Nucleotides(b) Nucleosides(c) Amino acids(d) HistonesThe question was asked in an interview for job.I would like to ask this question from Nucleotides & Nucleic Acids Basics topic in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» The correct option is (a) Nucleotides |
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| 18. |
Which of the following statements is true?(a) The template strand matches the sequence of the RNA transcript(b) The two strands of DNA run parallel to each other(c) G-C bonds are much more resistant to denaturation than A-T rich regions(d) The common form of DNA is left handedThis question was posed to me in an online quiz.The doubt is from Nucleic Acid Structure in portion Nucleotides and Nucleic Acids of Biochemistry |
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Answer» The correct choice is (c) G-C BONDS are much more resistant to DENATURATION than A-T RICH regions |
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| 19. |
According to Chargaff’s rule, in a DNA molecule ____________(a) The amount of adenine and thymine is equal to the amount of guanine and cytosine(b) The amount of adenine and guanine is equal to the amount of thymine and cytosine(c) The amount of adenine and uracil is equal to the amount of guanine and cytosine(d) The amount of adenine and guanine is equal to the amount of uracil and cytosineThis question was addressed to me during an internship interview.This is a very interesting question from Nucleic Acid Structure topic in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Correct OPTION is (a) The amount of ADENINE and thymine is equal to the amount of guanine and cytosine |
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| 20. |
DNA denaturation is measured by absorbance at ___________(a) 220nm(b) 230nm(c) 250nm(d) 260nmThis question was addressed to me in an interview for job.My question is from Nucleic Acid Chemistry in section Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Correct answer is (d) 260NM |
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| 21. |
Which of the following are not the components of RNA?(a) Thymine(b) Adenine(c) Guanine(d) CytosineI got this question by my school teacher while I was bunking the class.I would like to ask this question from Nucleotides & Nucleic Acids Basics in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» RIGHT answer is (a) Thymine The BEST I can explain: Thymine is PRESENT in DNA but not in RNA. |
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| 22. |
Which of the following is false about denaturation?(a) Disruption of hydrogen bonds(b) Disruption of phosphodiester linkage(c) Loss of helical structure of DNA(d) It is resulted as a result of change in pH or increase in temperatureI had been asked this question by my college director while I was bunking the class.The question is from Nucleic Acid Chemistry in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» CORRECT option is (b) DISRUPTION of phosphodiester linkage To EXPLAIN: Phosphodiester linkages are not broken by DENATURATION. |
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| 23. |
Which of the following is true about Z-DNA helix?(a) It has alternating GC sequences(b) It is a permanent conformation of DNA(c) It tends to be found at the 3’ end of the genes(d) It has fewer base pairs per turn than B-DNAThe question was posed to me in an internship interview.This intriguing question comes from Nucleic Acid Structure in section Nucleotides and Nucleic Acids of Biochemistry |
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Answer» The correct CHOICE is (a) It has alternating GC sequences |
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| 24. |
Number of hydrogen bonds between adenine and thymine?(a) 1(b) 2(c) 3(d) 4The question was asked in exam.This is a very interesting question from Nucleic Acid Structure topic in portion Nucleotides and Nucleic Acids of Biochemistry |
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Answer» CORRECT CHOICE is (b) 2 Easy explanation: A = T is the NOTATION for BONDING between A and T. |
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| 25. |
Which of the following leads to disruption of nucleosomal structure?(a) Acetylation(b) Carboxylation(c) Phosphorylation(d) MethylationI have been asked this question in a national level competition.Question is taken from Nucleic Acid Structure topic in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» Right choice is (d) METHYLATION |
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| 26. |
What happens in hypochromicity?(a) When DNA is in bound form, there is decrease in absorption of UV light(b) When DNA is in bound form, there is increase in absorption of UV light(c) When DNA is in unbound form, it is more stable(d) When DNA is in unbound form, there is decrease in absorption of UV lightThis question was addressed to me during an interview for a job.I want to ask this question from Nucleic Acid Chemistry in portion Nucleotides and Nucleic Acids of Biochemistry |
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Answer» The CORRECT option is (a) When DNA is in bound form, there is decrease in absorption of UV LIGHT |
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| 27. |
Which of the following statements is not true about RNA?(a) Does not have a double stranded structure(b) Thymine is present(c) Does not obey Chargaff’s rule(d) The sugar contained in RNA is a riboseI had been asked this question in exam.Question is from Nucleic Acid Structure topic in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» The CORRECT CHOICE is (b) THYMINE is present |
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| 28. |
Which one of the following nucleic acids has a left handed helix?(a) M-RNA(b) T-RNA(c) A-DNA(d) Z-DNAThis question was posed to me in a national level competition.The origin of the question is Nucleic Acid Structure in portion Nucleotides and Nucleic Acids of Biochemistry |
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Answer» The correct ANSWER is (d) Z-DNA |
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| 29. |
Arrangement of nucleotides in DNA can be seen by ____________(a) Ultracentrifuge(b) X-Ray crystallography(c) Light microscope(d) Electron microscopeI had been asked this question by my college director while I was bunking the class.The doubt is from Nucleic Acid Structure topic in chapter Nucleotides and Nucleic Acids of Biochemistry |
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Answer» The correct CHOICE is (b) X-Ray crystallography |
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| 30. |
Group of adjacent nucleotides are joined by ____________(a) Phosphodiester bond(b) Peptide bond(c) Ionic bond(d) Covalent bondI had been asked this question by my school principal while I was bunking the class.This interesting question is from Nucleotides & Nucleic Acids Basics in division Nucleotides and Nucleic Acids of Biochemistry |
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Answer» RIGHT option is (a) Phosphodiester bond The EXPLANATION is: The phosphodiester linkage joins 3’ CARBON ATOM of one sugar molecule and 5’ carbon atom of another carbon atom. |
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