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1.

An example of polar but uncharged amino acid is ___________(a) Lysine(b) Aspartate(c) Serine(d) ArginineI have been asked this question during an interview for a job.Question is taken from Types of Biological Molecules topic in portion Structures and Functions of Biological Molecules of Cell Biology

Answer»

Right choice is (C) SERINE

To explain I would say: LYSINE and ARGININE are polar and POSITIVELY charged amino acids. While Aspartate is a polar and negatively charged amino acid. Serine is a polar and uncharged amino acid.

2.

Which of the following is untrue?(a) Protein folding occurs in Golgi bodies(b) Protein folding is assisted by a protein molecule called Chaperone(c) Transmembrane or organelle proteins contain a signal peptide(d) Proteins are present in cytoplasm and cell organelles of all cellsI had been asked this question during an interview.This question is from Types of Biological Molecules topic in chapter Structures and Functions of Biological Molecules of Cell Biology

Answer»

Right option is (a) Protein folding occurs in Golgi bodies

The explanation: The folding of proteins occurs in the lumen of the ENDOPLASMIC RETICULUM (ER). A NEWLY synthesized protein undergoes a series of modifications in the ER with the help of a number of MOLECULAR chaperones and folding enzymes that all together assist its PROPER folding and subsequent release from ER. The majority of ER proteins are dedicated to the folding of proteins. Golgi bodies help in the proper packaging and transport of proteins.

3.

In RNA transcription, which of the following is a part of TBP-associated factor (TAF)?(a) TFIID(b) TFIIB(c) TFIIF(d) TFIIHI got this question in class test.My question is based upon Types of Biological Molecules in section Structures and Functions of Biological Molecules of Cell Biology

Answer» CORRECT choice is (a) TFIID

Easiest EXPLANATION: TFIID includes the TBP subunit which binds to the TATA box along with some other proteins, together known as the TBP-associated factors. TFIIB provides a binding site for RNA Polymerase. TFIIF CONTAINS a special subunit which is bound to the entering RNA Polymerase. TFIIH contains 10 SUBUNITS, 3 of which POSSESS enzymatic activity.
4.

RNA does not have the nitrogen base of _______(a) Uracil(b) Cytosine(c) Thymine(d) AdenineThe question was asked by my college professor while I was bunking the class.This intriguing question comes from Types of Biological Molecules in portion Structures and Functions of Biological Molecules of Cell Biology

Answer» CORRECT CHOICE is (c) Thymine

The explanation is: RNA does not have the pyrimidine Thymine and has Uracil INSTEAD while DNA has Thymine. In RNA, Adenine binds to Uracil with two hydrogen BONDS while in DNA, Adenine binds to Thymine by two hydrogen bonds.
5.

Which of the following amino acids may or may not be protonated at neutral pH?(a) Glutamate(b) Lysine(c) Histidine(d) ArginineThe question was asked in my homework.My query is from Biological Molecules Structures and Functions in section Structures and Functions of Biological Molecules of Cell Biology

Answer»

Right OPTION is (c) Histidine

To EXPLAIN: The amino acids may be negatively CHARGED, positively charged or neutral at a neutral pH. Here, Arginine and Lysine are positively charged or protonated at neutral pH, while Glutamate is negatively charged at neutral pH. However, Histidine may or may not be protonated at normal pH. The side chain of Histidine has a pKa of 6.5, which MEANS only 10% of Histidine is protonated.

6.

Proteome is a ____________(a) A precursor of protein(b) Storehouse of proteins(c) An inventory of the total amount of proteins(d) None of the mentionedThe question was posed to me in class test.The origin of the question is Types of Biological Molecules in portion Structures and Functions of Biological Molecules of Cell Biology

Answer» RIGHT option is (c) An inventory of the total amount of proteins

Easiest explanation: The entire inventory of proteins that is produced by an ORGANISM is known as that organism’s proteome. It may be ALSO applied to the inventory of proteins in a particular TISSUE or cell. PROTEOMICS is the field of protein biochemistry.
7.

The electron clouds around the nucleus are of ___________(a) Spherical shape(b) Spherical and Dumbbell shape(c) Spherical and Hexagonal shape(d) Cannot be determinedI had been asked this question in an international level competition.This intriguing question comes from Biological Molecules Structures and Functions topic in division Structures and Functions of Biological Molecules of Cell Biology

Answer» RIGHT option is (b) Spherical and Dumbbell shape

The explanation is: Electrons swarm around the nucleus of an atom in a MOSTLY unpredictable fashion. Erratic electron BEHAVIOUR is best described by the electron cloud model. The electron cloud is an area around the nucleus of an atom where electrons are most LIKELY to be FOUND. The clouds are roughly defined by their boundaries which is either spherical or dumbbell shape.
8.

Which of the following is functionally the odd one out?(a) siRNA(b) miRNA(c) shRNA(d) snRNAThis question was posed to me in examination.This interesting question is from Types of Biological Molecules topic in section Structures and Functions of Biological Molecules of Cell Biology

Answer»

Correct option is (d) snRNA

Easy explanation: micro RNA(miRNA) is a SMALL non-coding RNA that helps in gene silencing. Small interfering RNA (siRNA) helps in gene silencing through the RNA interference pathway. Short HAIRPIN RNA (shRNA) SILENCES TARGET gene via RNA interference. However, small NUCLEAR RNA or snRNA helps in RNA splicing and processing.

9.

Example of a polar amino acid is ____________(a) Glutamine(b) Alanine(c) Methionine(d) ValineI got this question in a national level competition.My query is from Types of Biological Molecules in chapter Structures and Functions of Biological Molecules of Cell Biology

Answer» CORRECT option is (a) Glutamine

Easy EXPLANATION: Glutamine is a POLAR but non-charged AMINO acid. ALANINE, Valine and Methionine, on the other hand, are non-polar amino acids.
10.

Heparin is an example of ___________(a) Tertiary protein(b) Oligosaccharides(c) Glycoproteins(d) GlycosaminoglycanI got this question during a job interview.I need to ask this question from Biological Molecules Structures and Functions topic in section Structures and Functions of Biological Molecules of Cell Biology

Answer»

The correct choice is (d) GLYCOSAMINOGLYCAN

For EXPLANATION: A more complex STRUCTURES of polysaccharides is glycosaminoglycan (GAGs). Unlike other polysaccharides, they have an A-B-A-B where A and B represent two different sugars.An EXAMPLE of GAG is heparin, which is secreted by cells in lungs against tissue damage. Heparin prevents blood coagulation, enabling free FLOW of blood to heart or lungs.

11.

Which of the following is not a protein denaturant?(a) SDS(b) Phenol(c) DTT(d) Acetic acidThe question was posed to me in quiz.I'd like to ask this question from Types of Biological Molecules topic in portion Structures and Functions of Biological Molecules of Cell Biology

Answer»

The correct option is (d) ACETIC acid

To explain I would SAY: Sodium dodecyl sulfate or SDS is a strong denaturant of protein and is used in SDS-PAGE technique. DTT is OFTENTIMES used along with SDS to further denature proteins by reducing their disulfide bonds to ALLOW for better separation of proteins during electrophoresis. Phenol is used as a protein denaturant during isolation of RNA from plants.

12.

The detailed tertiary structure of a protein is determined by the ___________ technique.(a) HPLC(b) Spectrometry(c) X-ray(d) X-ray crystallographyI have been asked this question in unit test.My question is taken from Biological Molecules Structures and Functions topic in chapter Structures and Functions of Biological Molecules of Cell Biology

Answer»

The correct answer is (d) X-ray crystallography

Easy explanation: In X-ray crystallography technique, a crystal of the protein is bombarded by a thin beam of X-ray and the radiation that is scattered by the electrons of the protein’s atoms is allowed to strike a radiation sensitive plate or detector, forming an image of SPOTS. When these diffraction patterns are subjected to COMPLEX mathematical ANALYSIS, an investigator can work backward to derive the STRUCTURE responsible for producing the PATTERN.

13.

Which of the following bond is not present in DNA?(a) Phosphate bond(b) Hydrogen bond(c) VanderWaal’s force(d) Disulphide bondThis question was posed to me during an internship interview.My enquiry is from Biological Molecules Structures and Functions in division Structures and Functions of Biological Molecules of Cell Biology

Answer»

The correct choice is (d) Disulphide bond

The best I can explain: Disulphide bond is not present in a DNA MOLECULE. PHOSPHATE bond is present between two deoxy-nucleotides (dNTPs) of DNA. The nitrogen bases on the two strands of DNA have hydrogen bonds between them. ADENINE is connected THYMINE by 2 hydrogen bonds, GUANINE is bound to Cytosine by 3 hydrogen bonds. The base stacking in DNA is due to Vanderwaal’s force.

14.

Which of the following disaccharides have beta (1->4) bond?(a) Maltose and Sucrose(b) Maltose and Isomaltose(c) Lactose and Cellobiose(d) Sucrose and CellobioseI got this question in exam.The origin of the question is Types of Biological Molecules in section Structures and Functions of Biological Molecules of Cell Biology

Answer»

The correct option is (c) Lactose and Cellobiose

To EXPLAIN: Among the disaccharides, sucrose, maltose and isomaltose have ALPHA(1->4) GLYCOSIDIC bond. However, lactose, lactulose and sucrose have beta(1->4) glycosidic LINKAGE.

15.

Which of the following is true based on the strength of the bond?(a) Ionic > Covalent > Vanderwaal> Hydrogen(b) Covalent > Ionic > Vanderwaal > Hydrogen(c) Covalent > Ionic > Hydrogen > Vanderwaal(d) Covalent > Ionic > Hydrogen = VanderwaalThis question was addressed to me by my college professor while I was bunking the class.The origin of the question is Biological Molecules Structures and Functions topic in division Structures and Functions of Biological Molecules of Cell Biology

Answer»

Right choice is (b) Covalent > Ionic > Vanderwaal > HYDROGEN

The explanation: Intramolecular bonds are called covalent bonds and are far stronger that intermolecular forces (or bonds). The latter are usually ranked as follows: ionic > Vanderwaal > hydrogen. Hydrogen bonding includes inter MOLECULAR interactions with permanent dipoles (and partial charges) between hydrogen atoms and a few other elements. Vander WAALS interactions are based on random and instantaneous dipoles which last for fractions of a SECOND in long, polarizable bonds.

16.

Those part of the DNA or gene that contribute to the mRNA product is called _________(a) Introns(b) Intervening sequences(c) Exons(d) Split genesI got this question in an international level competition.Question is taken from Types of Biological Molecules in section Structures and Functions of Biological Molecules of Cell Biology

Answer»

Right OPTION is (C) Exons

Easy EXPLANATION: Intervening sequences, also called introns are the portions of DNA excluded during transcription and thus are not there in the mRNA product. Exons are the part of DNA transcribed to form mRNA. The genes with intervening sequences are called SPLIT genes.

17.

Which of the following is not true?(a) Steroids are built around a four-ringed hydrocarbon skeleton(b) Cholesterol, testosterone, progesterone are examples of steroids(c) Steroids are found in the cell membranes of both plant and animal(d) Cannot be determinedI have been asked this question in quiz.My question is from Biological Molecules Structures and Functions topic in division Structures and Functions of Biological Molecules of Cell Biology

Answer»

Correct OPTION is (c) STEROIDS are found in the cell membranes of both PLANT and animal

Easiest explanation: Cholesterol is a STEROID which is found in the cell membranes of animals. Cholesterol is largely absent from plant cells, which is why vegetable oils are considered “cholesterol-free”.

18.

Which of the following is a non-polar molecule?(a) Water(b) Ammonia(c) Ethylene(d) EthanolThe question was posed to me in exam.The origin of the question is Biological Molecules Structures and Functions in portion Structures and Functions of Biological Molecules of Cell Biology

Answer»

Right option is (c) Ethylene

Easiest explanation: Polar molecules occur when two atoms do not share ELECTRONS equally in a covalent bond. A dipole is formed, with part of the molecule CARRYING a slight POSITIVE charge and the other part carrying a slight negative charge. This happens when there is a difference between the electronegativity of each atom. An extreme difference forms an ionic bond, while a lesser difference forms a polar covalent bond. When molecules share electrons equally in a covalent bond there is no NET electrical charge ACROSS the molecule. In a nonpolar covalent bond, the electrons are evenly distributed.

19.

Which of the following RNA is artificially made?(a) snRNA(b) scRNA(c) miRNA(d) siRNAI have been asked this question during an interview for a job.Query is from Types of Biological Molecules in portion Structures and Functions of Biological Molecules of Cell Biology

Answer»

Correct choice is (b) scRNA

Best explanation: siRNA, SNRNA and miRNA are all PRODUCED naturally in the cell. Small cytoplasmic RNA (scRNA) is an ENGINEERED (artificial) RNA MOLECULE that HELPS in in-vitro and in-vivo signal transduction.

20.

Atoms or molecules having orbitals containing a single unpaired electron is known as ___________(a) Captions(b) Anions(c) Free radicals(d) CarbocationI got this question by my college professor while I was bunking the class.This intriguing question originated from Biological Molecules Structures and Functions topic in portion Structures and Functions of Biological Molecules of Cell Biology

Answer» RIGHT answer is (c) Free RADICALS

Explanation: Atoms or molecules that have orbitals containing a single unpaired ELECTRON are highly unstable. They are called free radicals. Free radicals may be formed when a covalent bond is broken such that each portion keeps one-half of the shared electrons. They may ALSO be formed when an atom or molecule accepts a single electron TRANSFERRED during an oxidation-reduction reaction.