Antihistamine drugs are antagonists for which receptor?(a) H1 receptor antagonist(b) H2 receptor antagonist(c) H3 receptor antagonist(d) H4 receptor antagonistI have been asked this question at a job interview.Question is from Drug Concentration and Pharmacologic Response in division Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Antihistamine drugs are antagonists for which receptor?(a) H1 receptor

1.	Antihistamine drugs are antagonists for which receptor?(a) H1 receptor antagonist(b) H2 receptor antagonist(c) H3 receptor antagonist(d) H4 receptor antagonistI have been asked this question at a job interview.Question is from Drug Concentration and Pharmacologic Response in division Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology
Answer» Correct choice is (a) H1 receptor antagonist For EXPLANATION: A drug that reduces or eliminates the effects mediated by the chemical histamine. True antihistamines produce a therapeutic EFFECT which will be mediated by negative MODULATION of histamine receptors. The term antihistamine only refers to H1 receptor antagonists. Antihistamines compete with histamine for BINDING sites at the receptors. Antihistamine cannot remove the histamine if it is already bound.

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