Capsules with bigger particles and intense packing have poor drug release and dissolution rate due to an increase in the pore size.(a) True(b) FalseThe question was posed to me in exam.My enquiry is from Dosage Form Factors Affecting Drug Absorption in chapter Absorption of Drugs of Drug Biotechnology

Capsules with bigger particles and intense packing have poor drug rele

1.	Capsules with bigger particles and intense packing have poor drug release and dissolution rate due to an increase in the pore size.(a) True(b) FalseThe question was posed to me in exam.My enquiry is from Dosage Form Factors Affecting Drug Absorption in chapter Absorption of Drugs of Drug Biotechnology
Answer» Correct choice is (b) False Best explanation: Compression FORCE while the making of tablet and PACKING density (capsule packing) can INHIBIT or promote dissolution. Capsules with fine particles and intense packing have poor drug release and dissolution due to a decrease in the pore size between the molecules. THUS giving them poor penetrability into the GI fluids.

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