1.

Clearance is inversely related to volume of distribution.(a) True(b) FalseThis question was posed to me in an international level competition.The question is from Drugs Excretion topic in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology

Answer»

Correct CHOICE is (a) True

The best I can explain: The clearance decreases when a DRUG has a large VOLUME of distribution. A drug with large Vd is POORLY excreted in URINE. Blood restricted to blood compartments have higher excretion rates.



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