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Example of a drug which has PKa > 11 is ________(a) Cromolyn(b) Imipramine(c) Amitriptyline(d) MecamylamineI have been asked this question in an online quiz.I would like to ask this question from Drugs Absorption topic in chapter Absorption of Drugs of Drug Biotechnology

Answer» RIGHT answer is (d) MECAMYLAMINE

Explanation: Cromolyn pKa is 2.5. Imipramine and amitriptyline have pKa range from 5 to 11. Mecamylamine has pKa range GREATER than 11. These drugs are ionized in the ENTIRE pH range of GIT and thus they are poorly absorbed.


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