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Example of a drug which has PKa > 11 is ________(a) Cromolyn(b) Imipramine(c) Amitriptyline(d) MecamylamineI have been asked this question in an online quiz.I would like to ask this question from Drugs Absorption topic in chapter Absorption of Drugs of Drug Biotechnology |
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Answer» RIGHT answer is (d) MECAMYLAMINE Explanation: Cromolyn pKa is 2.5. Imipramine and amitriptyline have pKa range from 5 to 11. Mecamylamine has pKa range GREATER than 11. These drugs are ionized in the ENTIRE pH range of GIT and thus they are poorly absorbed. |
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