For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?(a) 1.50 ml/mm(b) 1.75 ml/mm(c) 2.75 ml/mm(d) 3 ml/mmThis question was posed to me at a job interview.My question is taken from Drugs Excretion topic in division Prodrugs & Excretion of Drugs of Drug Biotechnology

For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug

1.	For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?(a) 1.50 ml/mm(b) 1.75 ml/mm(c) 2.75 ml/mm(d) 3 ml/mmThis question was posed to me at a job interview.My question is taken from Drugs Excretion topic in division Prodrugs & Excretion of Drugs of Drug Biotechnology
Answer» Right option is (B) 1.75 ml/mm For explanation: The EQUATION for bile clearance is biliary excretion RATE/ plasma drug concentration. Since biliary excretion can ALSO be written as bile flow * biliary drug concentration. The other equation for bile clearance is bile flow * biliary drug concentration/ plasma drug concentration. Thus the answer is 0.720.8=1.75 ml/mm.

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