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For oral formulation, what should be the minimum aqueous solubility to avoid bioavailability problems?(a) 0.9%(b) 1%(c) 2%(d) 0.11%The question was posed to me in an online quiz.Origin of the question is Drugs Absorption in section Absorption of Drugs of Drug Biotechnology

Answer»

Right OPTION is (b) 1%

For explanation I WOULD say: Experiments have shown that a drug should have a minimum aqueous SOLUBILITY of 1% to avoid BIOAVAILABILITY PROBLEMS. Lesser than that it becomes a very serious issue for the drug to dissolve and give the proper effect.



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