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Heroin with pKa 7.8 will be in which form in intestinal pH?(a) Ionized form mostly(b) Unionized form mostly(c) Half ionized and half no ionized(d) Will form aggregateThe question was asked in quiz.My question comes from Drugs Absorption topic in portion Absorption of Drugs of Drug Biotechnology

Answer»

Right choice is (b) Unionized FORM mostly

The best I can explain: DRUGS that are moderately weak bases with pKa 5-11 will get ionized at gastric pH, stay unionized at INTESTINAL pH and get ABSORBED through the intestinal wall. Thus, heroin being a weak base will stay at unionized condition in the intestinal pH. It will not form any aggregate.



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