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How is renal clearance expressed mathematically?(a) Rate of urinary excretion/plasma drug concentration(b) Plasma drug concentration/rate of urinary excretion(c) 1/ Plasma drug concentration(d) 1/rate of urinary excretionThis question was addressed to me in exam.My query is from Drugs Excretion topic in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology

Answer»

The CORRECT choice is (a) Rate of urinary excretion/plasma drug concentration

To elaborate: Renal CLEARANCE is defined as the VOLUME of plasma or blood which is completely cleared of the unchanged drug by the kidney per unit TIME. It is expressed as an equation that is the Rate of urinary excretion/plasma drug concentration. It is the sum of the rate of glomerular filtration and rate of secretion minus the rate of absorption to the plasma drug concentration.



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