How the absolute surface area of hydrophobic drugs can be converted to their effective surface area?(a) Use of surfactant(b) Use of Hydrophobic diluents(c) Use of surfactant and hydrophilic diluents(d) No need of doing micronizationThe question was posed to me by my school teacher while I was bunking the class.My doubt is from Drugs Absorption topic in division Absorption of Drugs of Drug Biotechnology

How the absolute surface area of hydrophobic drugs can be converted to

1.	How the absolute surface area of hydrophobic drugs can be converted to their effective surface area?(a) Use of surfactant(b) Use of Hydrophobic diluents(c) Use of surfactant and hydrophilic diluents(d) No need of doing micronizationThe question was posed to me by my school teacher while I was bunking the class.My doubt is from Drugs Absorption topic in division Absorption of Drugs of Drug Biotechnology
Answer» Right choice is (c) Use of surfactant and hydrophilic diluents Explanation: Use of surfactant as a WETTING agent DECREASES the interfacial TENSION and displaces the adsorbed AIR with the solvent and USING hydrophilic diluents coat the surface and render them hydrophilic.

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