How to prevent hepatic first-pass metabolism for corticosteroids?(a) Providing intravenously(b) Providing orally(c) Form esters and ether products(d) By enhancing lipophilicityThis question was addressed to me by my college director while I was bunking the class.This key question is from Prodrugs topic in portion Prodrugs & Excretion of Drugs of Drug Biotechnology

How to prevent hepatic first-pass metabolism for corticosteroids?(a) P

1.	How to prevent hepatic first-pass metabolism for corticosteroids?(a) Providing intravenously(b) Providing orally(c) Form esters and ether products(d) By enhancing lipophilicityThis question was addressed to me by my college director while I was bunking the class.This key question is from Prodrugs topic in portion Prodrugs & Excretion of Drugs of Drug Biotechnology
Answer» The correct option is (c) FORM esters and ETHER products The best explanation: Providing orally will have to pass through the hepatic 1st pass. Forming ETHERS and esters can prevent extensive first-pass hepatic metabolism. Propanol has the HIGH hepatic first pass, it is pro-drug hemisuccinate is resistant to esterases of the liver.

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