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Ibuprofen a weak acid, in the stomach will be present in which of the given form?(a) Ionized form mostly(b) Non-ionized form mostly(c) Half ionized and half no ionized(d) Will form aggregateI got this question in quiz.The above asked question is from Drugs Absorption in portion Absorption of Drugs of Drug Biotechnology

Answer»

The correct answer is (b) Non-ionized form mostly

To explain I WOULD say: The pH of the STOMACH is 1.5. Ibuprofen being a WEAK acid will be in a UNIONIZED form in the stomach. At pH 7.4 in plasma, it will be in ionized form and in the same format pH 5 in the intestine.



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