Nitrazepam a weak base, will be in which form in the stomach?(a) Ionized form mostly(b) Non-ionized form mostly(c) Half ionized and half no ionized(d) Will form aggregateI have been asked this question in examination.I'd like to ask this question from Drugs Absorption in division Absorption of Drugs of Drug Biotechnology

Nitrazepam a weak base, will be in which form in the stomach?(a) Ioniz

1.	Nitrazepam a weak base, will be in which form in the stomach?(a) Ionized form mostly(b) Non-ionized form mostly(c) Half ionized and half no ionized(d) Will form aggregateI have been asked this question in examination.I'd like to ask this question from Drugs Absorption in division Absorption of Drugs of Drug Biotechnology
Answer» CORRECT answer is (a) IONIZED form mostly Explanation: The pH of the stomach is 1.5. Nitrazepam being a weak BASE will be in an ionized form in the stomach. In plasma and SMALL intestine with pH 7.4 and 5 respectively, Nitrazepam will be in UNIONIZED form.

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