So.  I used spybot, ccleaner, norton, ad-aware in safemode.  Norton and ad-aware found nothing, but spybot and ccleaner found over 150 issues, programs, files, etc.  Yet, my computer still is driving me crazy with the same popups.  I use Mozilla and they open up new tabs and RESIZE my internet window.  The popups are from partypoker (I've never been there), heavy.com, telling me I need disk cleaners, stopzilla, etc.  What else can I do?  I work out of my home and this only began last Friday [highlight]when I let my mother do something-or-other on it.[/highlight]  I also tried a system restore, but that didn't do anything.  Not that I really expected it to ...

That would be an important bit of info to find out.

You may be so compromised you get to reinstall Windows. (Do you have a real Windows CD, by the WAY?)

But try running Hijack This and post a log file here after you run ALL of those SCANS again in Safe Mode with System Restore turned off.  

http://www.majorgeeks.com/download3155.htmldid you do all of the scans in safe mode with the system restore off??Yes, I did.  And I kept it in safemode and ran the scans multiple times until they all came back clean.

It did not work.ok http://noahdfear.geekstogo.com/click%20counter/click.php?id=1

save that to your desktop extract the file to their own folder.. go into safe mode and run "runthis".bat


if that doesnt work check your host filesTurn off the Messenger service. To do this, follow these steps:
1.      Click START, and then click Control Panel (or point to Settings, and then click Control Panel).
2.      Double-click Administrative Tools.
3.      Double-click Services.
4.      Double-click Messenger.
5.      In the Startup type list, click Disabled.
6.      Click STOP, and then click OK.

If you are networked, get a router and a decent firewall - not windows built in crap. If you find that you actually need Messener service running, go to:
http://www.grc.com/stm/shootthemessenger.htm
This 22 byte utility will allow you to turn it on or off at will.