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Synthesis of histamine needs the enzyme histidine decarboxylase.(a) True(b) FalseThis question was posed to me in examination.This intriguing question originated from Drug Concentration and Pharmacologic Response in division Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Answer»

Correct choice is (a) True

The best explanation: HISTAMINE, when released, causes inflammation by increasing vasodilation, capillary PERMEABILITY, causing SMOOTH muscle contraction, mucus secretion, and parasympathetic NERVE stimulation. Formed from the AMINO acid Histidine in a decarboxylation reaction with the enzyme histidine decarboxylase. Occurs primarily in mast cells and basophils.



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