Related InterviewSolutions

• Which of the following is true regarding the methods of gene prediction?(a) They solely consist of a type called ab initio–based methods(b) The ab initio–based approach predicts genes based on the given sequence alone(c) The ab initio–based approach predicts genes based on the given sequence and relative homology data(d) They solely consist of a type called homology-based approachesThe question was posed to me in homework.I need to ask this question from Categories of Gene Prediction Programs in section Gene and Promoter Prediction of Bioinformatics
• The putative ORF can be translated into a protein sequence, which is then used to search against a protein database.(a) True(b) FalseThis question was posed to me in semester exam.This intriguing question originated from Gene Prediction in Prokaryotes topic in division Gene and Promoter Prediction of Bioinformatics
• Which of the following is untrue about EST2Genome?(a) It is a web-based program purely based on the sequence alignment approach to define intron–exon boundaries(b) It compares an EST (or cDNA) sequence with a genomic DNA sequence containing the corresponding gene(c) The alignment is rarely done using a dynamic programming–based algorithm(d) Advantage of the approach is the ability to find very small exons and alternatively spliced exons that are very difficult to predict by any ab initio–type algorithmsI got this question in a national level competition.Query is from Gene Prediction in Eukaryotes topic in portion Gene and Promoter Prediction of Bioinformatics
• GENSCAN is awebbased program that makes predictions based on fifth-order HMMs.(a) True(b) FalseI had been asked this question in a job interview.My query is from Gene Prediction in Eukaryotes in section Gene and Promoter Prediction of Bioinformatics
• The use of Markov models in gene finding exploits the fact that oligonucleotide distributions in the coding regions are different from those for the noncoding regions.(a) True(b) FalseThe question was asked at a job interview.This interesting question is from Gene Prediction in Prokaryotes topic in portion Gene and Promoter Prediction of Bioinformatics
• The presence of these codons at The beginning of the frame _____ give a clear indication of the translation initiation site.(a) always(b) does not necessarily(c) does not(d) neverI had been asked this question in final exam.My question is from Gene Prediction in Prokaryotes topic in portion Gene and Promoter Prediction of Bioinformatics
• In the ab initio–based approaches—they rely on two major features associated with genes: one of thembeing gene content, which is statistical description of coding regions.(a) True(b) FalseThis question was posed to me in homework.This key question is from Categories of Gene Prediction Programs in chapter Gene and Promoter Prediction of Bioinformatics
• RBS finder is a UNIX program that uses the prediction output from Glimmer and searches for the Shine–Delgarno sequences in the vicinity of predicted start sites.(a) True(b) FalseI have been asked this question in final exam.My enquiry is from Categories of Gene Prediction Programs topic in section Gene and Promoter Prediction of Bioinformatics
• Which of the following is untrue about Homology-Based Programs?(a) They are based on the fact that exon structures and exon sequences of related species are less conserved(b) This approach assumes that the database sequences are correct(c) It is a reasonable assumption in light of the fact that many homologous sequences to be compared with are derived from cDNA or expressed sequence tags (ESTs) of the same species(d) Potential coding frames in a query sequence are translated and used to align with closest protein homologs found in databasesThe question was posed to me by my college director while I was bunking the class.My question is taken from Gene Prediction in Eukaryotes topic in section Gene and Promoter Prediction of Bioinformatics
• Which of the following is a wrong statement?(a) Prokaryotes include bacteria and Archaea(b) Prokaryotes have relatively large genomes(c) Prokaryotes have relatively small genomes(d) In Prokaryotes, The gene density in the genomes is high, with more than 90% of a genome sequence containing coding sequenceThe question was asked in semester exam.Question is taken from Gene Prediction in Prokaryotes in division Gene and Promoter Prediction of Bioinformatics