What are the characteristics of 2^nd generation h1 receptor antagonists?(a) Selective for peripheral H1 receptors(b) Opposed to CNS H1 receptors(c) Selective for peripheral H1 receptors and opposed to CNS receptors(d) Selective to H1 receptors of CNSThis question was addressed to me during an interview.The query is from Drug Concentration and Pharmacologic Response topic in portion Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

What are the characteristics of 2^nd generation h1 receptor antagonist

1.	What are the characteristics of 2^nd generation h1 receptor antagonists?(a) Selective for peripheral H1 receptors(b) Opposed to CNS H1 receptors(c) Selective for peripheral H1 receptors and opposed to CNS receptors(d) Selective to H1 receptors of CNSThis question was addressed to me during an interview.The query is from Drug Concentration and Pharmacologic Response topic in portion Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology
Answer» CORRECT choice is (c) Selective for peripheral H1 receptors and opposed to CNS receptors Explanation: These are the newer drugs and they are MUCH more selective for the peripheral H1-receptors involved in allergies as opposed to the H1-receptors in the CNS. Therefore, these drugs provide the same relief with MANY fewer ADVERSE SIDE effects.

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