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What helps the ionized drug molecules to pass through the cell membrane passively?(a) Different pH(b) Polar group(c) Large lipophilic group(d) HydrationI have been asked this question in unit test.My question comes from Drugs Absorption topic in portion Absorption of Drugs of Drug Biotechnology

Answer»

The CORRECT choice is (c) LARGE LIPOPHILIC GROUP

Easiest explanation: Ionised drugs if ATTACHED with a large lipophilic group in their structure. This helps them in getting absorbed passively e.g. morphine derivatives.



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