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What is fluctuation?(a) Cmax/Cmin(b) Cmin / Cmax(c) 1/Cmin(d) 1/CmaxThe question was asked during an interview.This is a very interesting question from Pharmacokinetic Principles Applications topic in section Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Answer»

The correct choice is (a) Cmax/Cmin

The BEST I can explain: Fluctuation is defined as the ratio between Cmax and Cmin. Greater the ratio greater fluctuations will be seen in the graph. Fluctuations depend upon the dosing frequency and half-life of the DRUG. It also depends upon the rate of absorption. Greatest fluctuation can be seen when the drug is ADMINISTERED as a i.v. BOLUS.



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