What is the end product of hydrolysis of Lidocaine?(a) 2, 6-Xylidine, N, N-Dimethylglycine(b) 2, 5- Xylidine, Dimethylglycine(c) Xylidine, glycine(d) 1, 6-XylidineThis question was posed to me in exam.Question is taken from Drugs Biotransformation in chapter Biotransformation of Drugs of Drug Biotechnology

What is the end product of hydrolysis of Lidocaine?(a) 2, 6-Xylidine,

1.	What is the end product of hydrolysis of Lidocaine?(a) 2, 6-Xylidine, N, N-Dimethylglycine(b) 2, 5- Xylidine, Dimethylglycine(c) Xylidine, glycine(d) 1, 6-XylidineThis question was posed to me in exam.Question is taken from Drugs Biotransformation in chapter Biotransformation of Drugs of Drug Biotechnology
Answer» Correct choice is (a) 2, 6-Xylidine, N, N-Dimethylglycine Explanation: The reaction of hydrolysis of amides is catalysed by amidases. Lidocaine is a SECONDARY amide with an ORGANIC substituent on N-atom. THUS providing us with 2, 6-Xylidine, N, N-Dimethylglycine as the end product.

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