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How are electrophiles generated?(a) Through cytochrome P-450 system(b) NADPH cytochrome P-450 reductase(c) Different Flavin containing reductase(d) Through cytochrome P-350 systemThe question was posed to me in semester exam.Enquiry is from Bioactivation and Tissue Toxicity in chapter Biotransformation of Drugs of Drug Biotechnology

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Right answer is (a) Through cytochrome P-450 system

Explanation: Electrophiles are species deficient in ELECTRON pair. The enzyme system through which they are generated is cytochrome-P450. Carbon, nitrogen, SULPHUR COMPOUNDS can be metabolically activated to yield electrophiles.



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